Results 21 to 30 of about 236,762 (343)
The Journal of Reproduction and Development, 2023 Dynamic changes in the endometrium are crucial for establishing early pregnancy in ruminants. Blastocyst elongation and implantation require hormones and nutrients to be secreted from the maternal endometrium.
Meijun SONG +6 more
doaj +1 more source
Autophagy, 2023 SARS-CoV-2 poses a substantial global threat owing to the emergence of several highly transmissible variants. Autophagy is an intracellular degradation process that maintains cellular homeostasis and combats the invading pathogens. SARS-CoV-2 can trigger
Pengtao Jiao +13 more
semanticscholar +1 more source
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning [PDF]
Autophagy, 2012 Recent studies have suggested that autophagy plays a prosurvival role in ischemic preconditioning (IPC). This study was taken to assess the linkage between autophagy and endoplasmic reticulum (ER) stress during the process of IPC. The effects of IPC on ER stress and neuronal injury were determined by exposure of primary cultured murine cortical neurons
Rui, Sheng +7 more
openaire +2 more sources
Crosstalk between endoplasmic reticulum stress response and autophagy in human diseases
Animal Cells and Systems, 2023 Cells activate protective mechanisms to overcome stressful conditions that threaten cellular homeostasis, including imbalances in calcium, redox, and nutrient levels.
Junhee Kwon, Jihyun Kim, Keun-Il Kim
semanticscholar +1 more source
ER-Phagy: Selective Autophagy of the Endoplasmic Reticulum [PDF]
Autophagy, 2007 Throughout their life, cells must maintain homeostasis while facing constantly fluctuating demands on their different organelles. A major mechanism for the homeostatic control of organelle function is the unfolded protein response (UPR), a signaling pathway that triggers a comprehensive remodeling of the endoplasmic reticulum (ER) and the biosynthetic ...
Sebastián, Bernales +2 more
openaire +2 more sources
Atlastins remodel the endoplasmic reticulum for selective autophagy [PDF]
Journal of Cell Biology, 2018 Specific receptors are required for the autophagic degradation of endoplasmic reticulum (ER), known as ER-phagy. However, little is known about how the ER is remodeled and separated for packaging into autophagosomes. We developed two ER-phagy–specific reporter systems and found that Atlastins are key positive effectors and also targets of ER-phagy ...
Jin Rui Liang +3 more
openaire +3 more sources
Ecotoxicology and Environmental Safety, 2021 Polybrominated diphenyl ethers are known to be toxic and impair thyroid function. However, the underlying molecular mechanisms are not well understood. We constructed a female Sprague-Dawley rat model to evaluate the role of endoplasmic reticulum stress,
Rulin Ma +7 more
doaj +1 more source
Degradation of the Endoplasmic Reticulum by Autophagy during Endoplasmic Reticulum Stress in Arabidopsis [PDF]
The Plant Cell, 2012 In this article, we show that the endoplasmic reticulum (ER) in Arabidopsis thaliana undergoes morphological changes in structure during ER stress that can be attributed to autophagy. ER stress agents trigger autophagy as demonstrated by increased production of autophagosomes.
Yimo, Liu +5 more
openaire +2 more sources
Frontiers in Aging Neuroscience, 2021 Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, and it is characterized by the selective loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc), as well as the presence of intracellular inclusions ...
H. Ren +3 more
semanticscholar +1 more source
Evidence for the involvement of lipid rafts localized at the ER-mitochondria associated membranes in autophagosome formation [PDF]
, 2016 Mitochondria-associated membranes (MAMs) are subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. This membrane scrambling between ER and mitochondria appears to play a critical role in the earliest steps of autophagy.
Faggioni, Alberto +9 more
core +2 more sources