Results 301 to 310 of about 236,762 (343)

ER-Phagy: Quality and Quantity Control of the Endoplasmic Reticulum by Autophagy.

Cold Spring Harbor Perspectives in Biology, 2022
The endoplasmic reticulum (ER) is the largest organelle and has multiple roles in various cellular processes such as protein secretion, lipid synthesis, calcium storage, and organelle biogenesis.
Haruka Chino, N. Mizushima
semanticscholar   +1 more source

Regulation of endoplasmic reticulum turnover by selective autophagy

Nature, 2015
The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins and organelle communication. Constant ER turnover and modulation is needed to meet different cellular requirements and autophagy has an important role in this process ...
Aliaksandr Khaminets, Theresa Heinrich, M. Mari, P. Grumati, A. Huebner, M. Akutsu, L. Liebmann, Alexandra Stolz, S. Nietzsche, Nicole Koch, Mario Mauthe, I. Katona, B. Qualmann, J. Weis, F. Reggiori, I. Kurth, C. Hübner, I. Dikič   +17 more
semanticscholar   +7 more sources

Cardioprotection by Endoplasmic Reticulum Stress–Induced Autophagy

Antioxidants & Redox Signaling, 2011
This study tested the hypothesis that the induction of autophagy by producing therapeutic amounts of endoplasmic reticulum (ER) stress in the heart before an ischemic insult would ameliorate/reduce subsequent lethal myocardial ischemic/reperfusion (I/R) injury (similar to ischemic preconditioning).
Goran, Petrovski, Somak, Das, Bela, Juhasz, Attila, Kertesz, Arpad, Tosaki, Dipak K, Das   +5 more
openaire   +2 more sources

Ginsenoside CK induces apoptosis of human cervical cancer HeLa cells by regulating autophagy and endoplasmic reticulum stress.

Food & Function, 2021
Ginsenoside CK (GCK), as a metabolite of ginsenoside Rb1, has been studied for its anti-cancer activity. However, its in-depth anti-cancer mechanism on cervical cancer (CC) HeLa cells has not been fully elucidated. This study found that GCK inhibited the
Q. Yin, Hua Chen, Runhui Ma, Yuan-yuan Zhang, Miao-Miao Liu, K. Thakur, Jian-Guo Zhang, Zhao‐Jun Wei   +7 more
semanticscholar   +1 more source

Eating the endoplasmic reticulum: quality control by autophagy

Trends in Cell Biology, 2007
Autophagy is connected to a surprising range of cellular processes, including the stress response, developmental remodeling, organelle homeostasis and disease pathophysiology. The inducible, predominant form of autophagy, macroautophagy, involves dynamic membrane rearrangements, culminating in the formation of a double-membrane cytosolic vesicle, an ...
Tomohiro, Yorimitsu, Daniel J, Klionsky
openaire   +2 more sources

Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.

Journal of Dairy Science
Mastitis is a common disease in dairy cows and has various causes. Because of its enormous negative impact on cow health, welfare, and productivity, it results in huge economic losses and threatens sustainability of the dairy industry. In dairy cows with
Yue Yang, Ming Li, Jingyi Wang, Huijing Zhang, R. Chang, Bichen Zhao, B. Aernouts, Qingnian Huang, Chuang Xu   +8 more
semanticscholar   +1 more source

Endoplasmic Reticulum Stress and Autophagy in Cancer

2020
Endoplasmic Reticulum stress (ER stress) is a condition whereby unfolded and misfolded proteins accumulate in the ER lumen as a result of perturbation of the ER homeostasis. Nutrient deprivation, hypoxia, and calcium depletion are some conditions which can compromise the homeostasis of this compartment.
Mei Lan Tan, Heng Kean Tan, Tengku Sifzizul Tengku Muhammad   +2 more
openaire   +1 more source

Cypermethrin Induces Endoplasmic Reticulum Stress and Autophagy, Leads to Testicular Dysfunction

Science of The Total Environment, 2023
Cypermethrin is a pyrethroid insecticide that is used to control insects and protect crops. However, pesticide residues and their possible toxicity to non-target animals such as mammals are concerning. Although cypermethrin reduces testosterone levels, the molecular mechanisms involved, particularly those regarding endoplasmic reticulum (ER) stress and
Jiyeon, Ham, Hyewon, Jang, Gwonhwa, Song, Whasun, Lim   +3 more
openaire   +2 more sources

Autophagy and Endoplasmic Reticulum Stress

2017
Hypomorphic autophagy, a fundamental cellular catabolic process, has emerged as a key disease-specific theme associated with genetic risk for Crohn’s disease (CD), based on the original discovery of a nonsynonymous coding variation in the autophagy gene ATG16L1 and further autophagy risk genes discovered since then. Endoplasmic reticulum (ER) stress, a
openaire   +1 more source

Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells

Nephrology Dialysis Transplantation, 2009
Autophagy, an intracellular self-degradation system conserved throughout eukaryotes, plays an important role in a variety of biological processes, including cell death, development, cancer, defence against infection and neurodegeneration. However, little information about autophagy in renal tubular cells is available.
Takahisa, Kawakami, Reiko, Inagi, Hideki, Takano, Shigeru, Sato, Julie R, Ingelfinger, Toshiro, Fujita, Masaomi, Nangaku   +6 more
openaire   +2 more sources