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EI24 tethers endoplasmic reticulum and mitochondria to regulate autophagy flux
Cellular and Molecular Life Sciences, 2019Etoposide-induced protein 2.4 (EI24), located on the endoplasmic reticulum (ER) membrane, has been proposed to be an essential autophagy protein. Specific ablation of EI24 in neuronal and liver tissues causes deficiency of autophagy flux. However, the molecular mechanism of the EI24-mediated autophagy process is still poorly understood.
Lin Yuan +4 more
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Autophagy regulates insulin resistance following endoplasmic reticulum stress in diabetes
Journal of Physiology and Biochemistry, 2015Autophagy is a kind of cell biological process that maintains the cell's energy level under nutrient-poor conditions, regulates the turnover of abnormal or aged proteins, and disposes of dysfunctional organelles. The autophagy system is activated as a novel signaling pathway in response to endoplasmic reticulum stress (ER stress)-induced insulin ...
Ning, Zhang +4 more
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Autophagy and its link to the endoplasmic reticulum
Free Radical Biology and Medicine, 2018Autophagy is a conserved cellular process characterized by the de novo generation of double-membraned autophagosomes. It plays a significant role in promoting survival during periods of starvation when the increased generation of autophagosomes leads to the enclosure of bulk cytosol and the transport to the vacuole/lysosome where the protein content is
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Journal of Cellular Physiology, 2019
Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma.
M. Ashrafizadeh +5 more
semanticscholar +1 more source
Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma.
M. Ashrafizadeh +5 more
semanticscholar +1 more source
Endoplasmic reticulum stress and autophagy as targets for cancer therapy
Cancer Letters, 2009The endoplasmic reticulum stress (ERS) response represents an adaptive mechanism that supports survival and chemoresistance of tumor cells. Autophagy, although less well understood, has also been emerging as a means for tumor cells to increase survival under conditions of metabolic stress, hypoxia, and perhaps even chemotherapy.
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Autophagy and autophagy-related pathways in cancer
Nature Reviews Molecular Cell Biology, 2023, Kevin M Ryan
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