Results 31 to 40 of about 236,762 (343)
Animal Cells and Systems, 2022 Autophagy modulators are considered putative therapeutic targets because of the role of autophagy in cancer progression. Kazinol C, a 1,3-diphenylpropane from the plant Broussonetia kazinoki, has been shown to induce apoptosis in colon cancer cells ...
Yunkyeong Lee +4 more
doaj +1 more source
Advances in ER-Phagy and Its Diseases Relevance
Cells, 2021 As an important form of selective autophagy in cells, ER-phagy (endoplasmic reticulum-selective autophagy), the autophagic degradation of endoplasmic reticulum (ER), degrades ER membranes and proteins to maintain cellular homeostasis.
Lingang He, Xuehong Qian, Yixian Cui
doaj +1 more source
The endoplasmic reticulum in plant immunity and cell death [PDF]
, 2012 The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core +2 more sources
Endoplasmic reticulum and autophagy in rat hepatocytes. [PDF]
Proceedings of the National Academy of Sciences, 1978 Electron microscopy of hepatocytes in both normal rat liver and rat liver treated to induce hyperplasia of smooth endoplasmic reticulum shows that autophagic vacuoles and residual bodies (types of lysosomes) are continuous with endoplasmic reticulum.
A B, Novikoff, W Y, Shin
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Autophagy is a dynamic process that maintains the normal homeostasis of cells by digesting and degrading aging proteins and damaged organelles. The effect of autophagy on neural tissue is still a matter of debate.
Yahao Gao +8 more
semanticscholar +1 more source
Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame. [PDF]
, 2016 The endoplasmic reticulum (ER)-anchored hepatic cytochromes P450 (P450s) are enzymes that metabolize endo- and xenobiotics i.e. drugs, carcinogens, toxins, natural and chemical products.
Correia, Maria Almira +4 more
core +1 more source
Endoplasmic Reticulum Stress and Autophagy
, 2019 In 1945, K. R. Porter et al. observed mouse embryonic fibroblasts (MEFs) and found that the cytoplasmic part of the cell had an unreported reticular structure, so it was named endoplasmic reticulum (ER). The major functions of the endoplasmic reticulum are: synthesis of intracellular proteins and the modification and processing of proteins.
Zhihao, Qi, Linxi, Chen
openaire +5 more sources
Degradation of the endoplasmic reticulum by autophagy in plants [PDF]
Autophagy, 2013 Eukaryotic cells have developed sophisticated strategies to contend with environmental stresses faced in their lifetime. Endoplasmic reticulum (ER) stress occurs when the accumulation of unfolded proteins within the ER exceeds the folding capacity of ER chaperones. ER stress responses have been well characterized in animals and yeast, and autophagy has
Yimo, Liu, Diane C, Bassham
openaire +2 more sources
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway [PDF]
PeerJ, 2022 Catalpol significantly reduces triptolide-induced hepatotoxicity, which is closely related to autophagy. The aim of this study was to explore the unclear protective mechanism of catalpol against triptolide.
Linluo Zhang +11 more
doaj +2 more sources
Cell Death Discovery, 2022 2-Deoxyglucose (2-DG) can be used in antitumour research by inhibiting glycolysis and promoting the endoplasmic reticulum stress (ERS) pathway, but its clinical application is restricted due to dose-limiting side effects and survival chance for cancer ...
Ning Zhou +9 more
semanticscholar +1 more source