Results 41 to 50 of about 236,762 (343)
Endoplasmic Reticulum Stress: A New Pathway to Induce Autophagy [PDF]
Autophagy, 2007 Autophagy is a response to the stress of nutrient limitation in yeast, whereby cytosolic long-lived proteins and organelles are nonselectively degraded, and the resulting macromolecules are recycled to allow new protein synthesis that is essential for survival. We recently revealed that endoplasmic reticulum (ER) stress induces autophagy.
Tomohiro, Yorimitsu, Daniel J, Klionsky
openaire +2 more sources
Cancer Cell International, 2021 Cancers are serious life-threatening diseases which annually are responsible for millions of deaths across the world. Despite many developments in therapeutic approaches for affected individuals, the rate of morbidity and mortality is high.
S. Mehrzadi +4 more
semanticscholar +1 more source
Neuroprotection targeting protein misfolding on chronic cerebral hypoperfusion in the context of metabolic syndrome [PDF]
, 2018 Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH
Capani, Francisco +6 more
core +1 more source
Materials Research Express, 2021 Backgrounds. The cellular homeostasis is major maintained by the catabolic pathway of autophagy. Our previous work indicated that SWCNH were associated with endoplasmic reticulum (ER) stress mediated by calcium flow and autophagic response.
Jinling Dong +4 more
doaj +1 more source
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]
, 2010 ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E +7 more
core +2 more sources
Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes [PDF]
Diabetes, 2013 Accumulation of misfolded proinsulin in the β-cell leads to dysfunction induced by endoplasmic reticulum (ER) stress, with diabetes as a consequence. Autophagy helps cellular adaptation to stress via clearance of misfolded proteins and damaged organelles.
Bachar-Wikstrom, Etty +6 more
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Mitochondria‐Associated Endoplasmic Reticulum Membranes: Inextricably Linked with Autophagy Process
Oxidative Medicine and Cellular Longevity, 2022 Mitochondria‐associated membranes (MAMs), physical connection sites between the endoplasmic reticulum (ER) and the outer mitochondrial membrane (OMM), are involved in numerous cellular processes, such as calcium ion transport, lipid metabolism, autophagy, ER stress, mitochondria morphology, and apoptosis.
Chonghao Ji +8 more
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Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer
Tumor Biology, 2017 Pancreatic cancer is one of the most aggressive and difficult to treat cancers. Experimental and clinical evidence suggests that high basal state autophagy in pancreatic tumors could induce resistance to chemotherapy.
Alok Ranjan +4 more
doaj +1 more source
Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
core +3 more sources
Apoptosis, autophagy & endoplasmic reticulum stress in diabetes mellitus
Indian Journal of Medical Research, 2016 The prevalence of diabetes mellitus (DM) is increasing secondary to increased consumption of food and decreased physical activity worldwide. Hyperglycaemia, insulin resistance and hypertrophy of pancreatic beta cells occur in the early phase of diabetes.
Demirtas, Levent +6 more
openaire +2 more sources