Results 51 to 60 of about 236,762 (343)

Correction: Atlastins remodel the endoplasmic reticulum for selective autophagy [PDF]

Journal of Cell Biology, 2018
Vol. 217, No. 10, October 1, 2018. [10.1083/jcb.201804185][1]. The immunofluorescence image in [Figure 2][2] I was mislabeled as GFP-LC3B but is in fact immunofluorescence staining of endogenous LC3B.
Liang, Jin Rui, Lingeman, Emily, Ahmed, Saba, Corn, Jacob E.   +3 more
openaire   +2 more sources

Differences in the Intracellular Localization of Methylated β-Cyclodextrins-Threaded Polyrotaxanes Lead to Different Cellular States

Biomolecules, 2023
Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxane (Me-PRX)
Yuma Yamada, Shinnosuke Daikuhara, Atsushi Tamura, Kei Nishida, Nobuhiko Yui, Hideyoshi Harashima   +5 more
doaj   +1 more source

Urolithin A induces protective autophagy to alleviate inflammation, oxidative stress, and endoplasmic reticulum stress in pediatric pneumonia.

Allergologia et Immunopathologia, 2022
OBJECTIVE To investigate the therapeutic effect of urolithin A (UA) on pediatric pneumonia and the underlying mechanisms. METHODS The pediatric infantile pneumonia model was constructed by intratracheal induction of lipopolysaccharide (LPS) in 1-week ...
Xingli Cao, Hong Wan, Hao Wan
semanticscholar   +1 more source

Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]

, 2017
KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara, Faggioni, Alberto, Gilardini Montani, Maria Saveria, Gonnella, Roberta, Granato, Marisa, Romeo, Maria Anele, Santarelli, Roberta, Tiano, Mariangela Sara   +7 more
core   +2 more sources

Unfolded protein response and activated degradative pathways regulation in GNE myopathy.

PLoS ONE, 2013
Although intracellular beta amyloid (Aβ) accumulation is known as an early upstream event in the degenerative course of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) myopathy, the process by which Aβdeposits initiate various ...
Honghao Li, Qi Chen, Fuchen Liu, Xuemei Zhang, Wei Li, Shuping Liu, Yuying Zhao, Yaoqin Gong, Chuanzhu Yan   +8 more
doaj   +1 more source

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors [PDF]

, 2016
The synthetic steroid mifepristone blocks the growth of ovarian cancer cells, yet the mechanism driving such effect is not entirely understood. Unbiased genomic and proteomic screenings using ovarian cancer cell lines of different genetic backgrounds and
Callegari, Eduardo A., Chien, Jeremy, Drappeau, Donis D., Eyster, Kathleen M., Gamarra Luques, Carlos Diego, Goyeneche, Alicia A., Hapon, María Belén, Knapp, Jennifer R., Pan, Bo, Srinivasan, Rekha, Telleria, Carlos Marcelo, Terpstra, Erin J., Wang, Xuejun, Zhang, Lei   +13 more
core   +1 more source

Melatonin Induces Anti-Inflammatory Effects to Play a Protective Role via Endoplasmic Reticulum Stress in Acute Pancreatitis

Cellular Physiology and Biochemistry, 2016
Background/Aims: Melatonin, which is mainly secreted by the pineal gland and released into blood, has anti-inflammatory properties in acute pancreatitis. Many studies show that melatonin can relieve inflammation in taurocholate-induced acute pancreatitis.
Yina Chen, Jie Zhang, Qian Zhao, Qinfen Chen, Yangjie Sun, Yin Jin, Jiansheng Wu   +6 more
doaj   +1 more source

Endoplasmic Reticulum–Mitochondria Contact Sites and Neurodegeneration

Frontiers in Cell and Developmental Biology, 2020
Endoplasmic reticulum–mitochondria contact sites (ERMCSs) are dynamic contact regions with a distance of 10–30 nm between the endoplasmic reticulum and mitochondria.
Lingna Xu, Lingna Xu, Xi Wang, Xi Wang, Chao Tong, Chao Tong   +5 more
doaj   +1 more source

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform [PDF]

Developmental Cell, 2019
The dynamics and coordination between autophagy machinery and selective receptors during mitophagy are unknown. Also unknown is whether mitophagy depends on pre-existing membranes or is triggered on the surface of damaged mitochondria. Using a ubiquitin-dependent mitophagy inducer, the lactone ivermectin, we have combined genetic and imaging ...
Maria, Zachari, Sigurdur R, Gudmundsson, Ziyue, Li, Maria, Manifava, Fiorella, Cugliandolo, Ronak, Shah, Matthew, Smith, James, Stronge, Eleftherios, Karanasios, Caterina, Piunti, Chieko, Kishi-Itakura, Helena, Vihinen, Eija, Jokitalo, Jun-Lin, Guan, Folma, Buss, Andrew M, Smith, Simon A, Walker, Eeva-Liisa, Eskelinen, Nicholas T, Ktistakis   +18 more
openaire   +6 more sources

Portulaca oleracea L. Extract Ameliorates Intestinal Inflammation by Regulating Endoplasmic Reticulum Stress and Autophagy

Molecular Nutrition & Food Research, 2021
Scope To investigate the role of endoplasmic reticulum stress (ERS)‐induced autophagy in inflammatory bowel disease (IBD) and the intervention mechanism of Portulaca oleracea L.
Ziwei Zhang, D. Qiao, Ya-Li Zhang, Qian Chen, Yu-jun Chen, Yingjue Tang, R. Que, Ying Chen, Lie Zheng, YanCheng Dai, Zhi-Peng Tang   +10 more
semanticscholar   +1 more source