Results 121 to 130 of about 146,033 (236)

Developmental hypomyelination in Wolfram syndrome: New insights from neuroimaging and gene expression analyses [PDF]

, 2019
Wolfram syndrome is a rare multisystem disorder caused by mutations in WFS1 or CISD2 genes leading to brain structural abnormalities and neurological symptoms. These abnormalities appear in early stages of the disease.
Dougherty, Joseph, Hershey, Tamara, Marshall, Bess, Neyman, Olga, Park, Ki Yun, Rahn, Rachel, Samara, Ahmad, Samara, Amjad   +7 more
core   +1 more source

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier   +12 more
core   +2 more sources

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Endoplasmic reticulum stress in liver disease

Journal of Hepatology, 2011
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER) that are sensed by the binding immunoglobulin protein (BiP)/glucose-regulated protein 78 (GRP78). The accumulation of unfolded proteins sequesters BiP so it dissociates from three ER-transmembrane transducers leading to their ...
Harmeet Malhi, Randal J. Kaufman
openaire   +2 more sources

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Kogel, Karl-Heinz, Qiang, X., Reitz, M. U., Schäfer, Patrick, Zechmann, B.   +4 more
core   +2 more sources

Organic AIE Nanoradiosensitizer Potentiates X‐Ray Triggered Continuous Reactive Oxygen Species Generation for Potent Cancer Radioimmunotherapy

Advanced Materials, EarlyView.
Herein, a glutathione‐responsive system (named THN) is prepared for X‐ray‐triggered sustained ROS generation for efficient antitumor immunotherapy. The double‐promoting ROS generation of THN induced massive immunogenic cancer cell death and polarized M2 macrophages into the M1 phenotype for enhanced antitumor immunotherapy.
Qingyong Xu, Minmin Zhang, Qinqin Huang, Song Gao, Sitong Chu, Qi Li, Wanyao Chen, Xinglong Zhang, Tianfu Zhang, Ben Zhong Tang, Shipeng Ning   +10 more
wiley   +1 more source

The Endoplasmic Reticulum Stress of Placental Impoverishment [PDF]

The American Journal of Pathology, 2008
This Commentary discusses the key roles of protein synthesis-inhibition and endoplasmic reticulum (ER) stress in the pathophysiology of intrauterine growth restriction.
openaire   +4 more sources

The proteasome biogenesis regulator Rpn4 cooperates with the unfolded protein response to promote ER stress resistance

, 2019
Misfolded proteins in the endoplasmic reticulum (ER) activate the unfolded protein response (U PR), which enhances protein folding to restore homeostasis.
Borner, G., Schessner, J., Schmidt, R., Schuck, S.   +3 more
core   +1 more source

The Induction of Dendritic Cell Endoplasmic Reticulum Stress by Irradiated-Tumor Derived Extracellular Vesicles Supports the Adoption of a Pro-Tumor Phenotype [PDF]

, 2020
The Induction of Macrophage Endoplasmic Reticulum Stress by Irradiated-Tumor Derived Extracellular Vesicles Supports the Adoption of a Pro-Tumor Phenotype Sitara Mahmoodi, Depts. of Biology and Chemistry, with Dr. Sarah Golding, Dept.
Mahmoodi, Sitara
core   +1 more source

Flippase‐Mediated Hybrid Vesicle Division

Advanced Materials, EarlyView.
The successful reconstitution of Drs2p–Cdc50p flippase in small and giant polymer lipid hybrid vesicles is illustrated. The hybrid vesicles show adenosine 5′‐triphosphate consumption and flipping of 2‐dioleoyl‐sn‐glycero‐3‐phospho‐l‐serine lipids from the inner to the outer leaflet.
Paula De Dios Andres, Amalie Benfeldt Purup, Grégory Beaune, Jaakko V. I. Timonen, Joseph A. Lyons, Brigitte Städler   +5 more
wiley   +1 more source