Results 171 to 180 of about 462,885 (376)

Shedding Light on the Cellular Uptake Mechanisms of Bioactive Glass Nanoparticles as Controlled Intracellular Delivery Platforms: A Review of the Recent Literature

open access: yesAdvanced Healthcare Materials, EarlyView.
This review summarizes the main uptake pathways of bioactive glass nanoparticles (BGNs) and their intracellular localization, highlighting that BGNs are mainly internalized and entrapped within endosomes/lysosomes. Strategies for controlled intracellular ion release, with implications for targeted modulation of cell behavior, are discussed. The need to
Andrada‐Ioana Damian‐Buda   +1 more
wiley   +1 more source

MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke

open access: yesFrontiers in Cellular Neuroscience
Ischemic stroke (IS) is the predominant subtype of stroke and a leading contributor to global mortality. The mitochondrial-associated endoplasmic reticulum membrane (MAM) is a specialized region that facilitates communication between the endoplasmic ...
Ziyi Jia   +8 more
doaj   +1 more source

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

open access: yesAdvanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao   +2 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

open access: yesAdvanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen   +7 more
wiley   +1 more source

Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023

open access: yesFrontiers in Pharmacology
BackgroundThe glomerular podocyte endoplasmic reticulum is a critical component in renal function, yet its research landscape is not fully understood.
Wang Junli   +8 more
doaj   +1 more source

Herp, a New Ubiquitin-like Membrane Protein Induced by Endoplasmic Reticulum Stress [PDF]

open access: hybrid, 2000
Koichi Kokame   +3 more
openalex   +1 more source

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications

open access: yesAdvanced Materials, EarlyView.
A schematic illustration of how noble metals can be used to create nanoparticles (NPs) or nanoclusters (NCs). Noble metal NPs, due to their plasmonic properties, enable photothermal therapy and surface‐enhanced Raman scattering (SERS). In contrast, NCs, which lack a plasmonic resonance band, exhibit fluorescence, making them ideal for bioimaging ...
David Esporrín‐Ubieto   +3 more
wiley   +1 more source

The Bionic Interface: Considering the Material Mediated Electrical Stimulation of Stem Cells

open access: yesAdvanced Materials, EarlyView.
Electrical stimulation directs stem cell fate in tissue engineering. Cellular responses are influenced by membrane properties, intrinsic cell state, material charge‐transport characteristics, and the applied electrical signal. Additionally, a material’s ability to inject, store, and redistribute charge further modulates these responses.
Kaiwen Zhang   +6 more
wiley   +1 more source

Piperlongumine Inhibits Lung Cancer Growth by Inducing Endoplasmic Reticulum Stress Leading to Suppression of M2 Macrophage Polarization

open access: yesBiological Procedures Online
Lung cancer is the leading cause of cancer-related deaths globally. Prolonged targeted therapy use can lead to drug resistance and target mismatches, necessitating more effective and safer treatment strategies.
Yixin Zhou   +5 more
doaj   +1 more source

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