Animal Research and One Health, EarlyView.Cows with ketosis during the perinatal period often experience damage to the liver, a core metabolic organ, thereby exacerbating the disease's inherent vicious cycle. This study indicates that serum 3‐IAA concentrations were reduced in ketotic cows and show a significant negative correlation with hepatic TG content.
Dandan Qi +15 more
wiley +1 more source
Weight Loss During Obesity Provokes Asparaginase-Associated Liver Steatosis and Endoplasmic Reticulum Stress. [PDF]
FASEB JBhavsar CT +9 more
europepmc +1 more source
Modulation of Animal Gut Health by Milk Oligosaccharide
Animal Research and One Health, EarlyView.This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen +7 more
wiley +1 more source
Deciphering the interplay between hypoxia, angiogenesis, and endoplasmic reticulum stress in carcinogenesis: A narrative review. [PDF]
World J Exp MedBhardwaj S +4 more
europepmc +1 more source
Disulfide Bond–Modified Proteomics Reveals the Effects of Riboflavin on Protein Folding Dynamics
Animal Research and One Health, EarlyView.Riboflavin deficiency impairs oxidative protein folding, causing ER misfolded protein accumulation, CHOP activation, and apoptosis, revealing a role of riboflavin in proteostasis. ABSTRACT Riboflavin is a crucial micronutrient essential for maintaining cellular homeostasis, acting as an important precursor for flavoproteins that utilize flavin ...
Bo Zhang, Shuisheng Hou, Jing Tang
wiley +1 more source
Research hotspots and emerging trends in the regulation of endoplasmic reticulum stress by traditional Chinese medicine: A bibliometric analysis perspective. [PDF]
Medicine (Baltimore)Qian J, Yang W, Wang S, Xue H, Wu C.
europepmc +1 more source
Investigating the Role of Type I Interferon Signaling on Muscle Disease Using Mouse Models
Arthritis &Rheumatology, EarlyView.Objective Dysregulated type I interferon (IFN) signaling contributes to autoimmune myositis pathogenesis. We investigated the therapeutic effects of JAK inhibitors in two mouse models. We also examined how type I IFNs affect muscle vasculature. Methods Myositis was induced in major histocompatibility complex class I double transgenic ([TRE‐H‐2Kb (H ...
Rita Spathis +11 more
wiley +1 more source
Machine-learning assisted subclassification of glioblastoma by developing an endoplasmic reticulum stress-related methylation signature. [PDF]
Front OncolZhao J, Li M, Pu X, Guo Y.
europepmc +1 more source
Integrin β3 Promotes Retinal Neovascularization via Endoplasmic Reticulum Stress-Mediated Endothelial Cell Senescence. [PDF]
Invest Ophthalmol Vis SciQian Y, Song Y, Ma J.
europepmc +1 more source
Obesity as a Determinant of Periodontal Therapy Outcomes: Insights on Oxidative and Endoplasmic Reticulum Stress Pathways. [PDF]
Int Dent JHermenejildo J +12 more
europepmc +1 more source