Results 231 to 240 of about 230,735 (311)

Glucocorticoids injure the airway epithelial barrier via endoplasmic reticulum stress-related apoptosis in asthma. [PDF]

Front Pharmacol
You H, Zou W, Wang K, Gan T, Hu J, Tan W, Wang T, Ren L, Geng G, Fu Z, Niu C.   +10 more
europepmc   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Ectopic expression of MUC5B in the respiratory bronchiole initiates endoplasmic reticulum stress in the IPF lung. [PDF]

Am J Respir Cell Mol Biol
Blumhagen RZ, Kurche JS, Cool CD, Heinz D, Ma X, Davidson EJ, Fingerlin TE, Huber JP, Dobrinskikh E, Schwartz DA, Yang IV.   +10 more
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress [Retraction]. [PDF]

J Inflamm Res
europepmc   +1 more source

Oxidative stress and endoplasmic reticulum stress in acute kidney injury: mechanistic crosstalk and therapeutic modulation. [PDF]

Front Med (Lausanne)
Xu X, Xing Q, Li H, Ding Z, Ren X.
europepmc   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Non-canonical STING activation by calcium influx paired to endoplasmic reticulum stress. [PDF]

Cell Commun Signal
Rius-Rocabert S, Tur-Planells V, Arranz-Herrero J, Inchausti-Moya I, Miorin L, de Luis EV, Dopazo A, Solera RA, Concepcion AR, Gastaminza P, García-Sastre A, Nistal-Villan E.   +11 more
europepmc   +1 more source

A Metal‐Phenolic Nanocluster Orchestrates Mito‐Ca2+ Metabolic Autonomy for Tumor Ca2+ Interference Therapy

Advanced Science, EarlyView.
Tumor Ca2+ interference therapy suffers from self‐protective Ca2+ metabolic autoregulation. In this scenario, a versatile metal‐phenolic nanocluster (TCMH) is engineered to modulate mitochondrial calcium uniporter (MCU) ‐mediated mito‐Ca2+ metabolic autonomy.
Ronglong Chen, Jia Huang, Yuepeng Wang, Shucong Yao, Fei Wu, Juan Liu, Chunxue Song, Li Lin, Xijun Lin, Yingjie Deng, Chao Zhang, Zhiquan Huang, Zixian Huang, Lisi Xie   +13 more
wiley   +1 more source

Wntless degradation mediated by CaMKII inhibition drives endoplasmic reticulum stress and apoptosis. [PDF]

Cell Rep
Gu Z, Owiredu J, Ersoy-Fazlioglu B, Wu B, Lu M, Balk SP, Yuan X.   +6 more
europepmc   +1 more source