Results 321 to 330 of about 462,885 (376)

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, EarlyView.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

Overactivation of PERK-Mediated Endoplasmic Reticulum Stress-Induced Testis Damage in Chronically Stressed Mice. [PDF]

ACS Omega
Peng L, Tang X, Tang P, Zhou C, Xiang Y, Cao W, Li Y, Peng C, Xu Y, Li S.   +9 more
europepmc   +1 more source

ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ACE can modulate the CBL‐mediated K48 ubiquitination degradation of PSAP by altering its glycosylation levels in NP cells. As a result, NP cells secrete PSAP, which interacts with GPR37 on macrophage surfaces, facilitating their polarization toward the M2 phenotype. These M2 macrophages subsequently secrete TGFβ, which exerts feedback effects on the NP
Youfeng Guo, Feng Wang, Bijun Wang, Yu Zhou, Chao Wang, Tao Hu, Desheng Wu   +6 more
wiley   +1 more source

PMAIP1 mediates endoplasmic reticulum stress in human dental pulp stem cells during pulpitis pathogenesis. [PDF]

BMC Oral Health
Zhou C, Zhang J, Chen L, Yu Y, Sun Y, Pan Y, Cai S, Zhong P.   +7 more
europepmc   +1 more source

Partial Reprogramming in Senescent Schwann Cells Enhances Peripheral Nerve Regeneration via Restoration of Stress Granule Homeostasis

Advanced Science, EarlyView.
In this study, it is discovered that pathological accumulation of Runx2+ Schwann cell clusters​ during axonal regeneration is a key factor impairing nerve repair in aging. This pathology is associated with ​dysregulation of stress granule homeostasis.
Peilin Wang, Renyuan Wang, Yilin Huo, Ying Peng, Chuanliang Fu, Yi Hu, Zun Ren, Yersen Mulat, Hao Zhang, Dongsheng Jiang, Haodong Lin   +10 more
wiley   +1 more source

Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy. [PDF]

Sci Rep
Li T, Li L, Sun Z, Zeng H, He G, Tian Z, Chen D, Li J.   +7 more
europepmc   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Research Hotspots and Trends of Endoplasmic Reticulum Stress in Obesity From 2014 to 2024: A CiteSpace Visualization Analysis. [PDF]

Cureus
Zhang X, Kang M, Cai Y, Jin J, Guo S, Liu Y.   +5 more
europepmc   +1 more source

Tumor Cell‐Derived CXCL2 Potentiates Neutrophil‐Mediated Antitumor Immunity by Inhibiting Cholesterol Biosynthesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study identifies the unconventional role of CXCL2 in regulating neutrophil polarization and immune responses in HCC. Unlike the common view that CXCL2 acts mainly as an extracellular chemokine, intracellular CXCL2 can interact with YBX1 and prevent its nuclear translocation.
Xin Liu, Danli Yang, Qianqian Jiang, Meng Han, Zhao Zhou, Yukun Li, Yu Wu, Jingzhou Wang, Ting Zhang, Guohua Lou, Guochao Wei, Lin Wang, Fengmin Lu, Xiangmei Chen   +13 more
wiley   +1 more source