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Endoplasmic Reticulum Stress in Neurodegeneration
2008Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response called the unfolded protein response (UPR) that protects the cell against the toxic buildup of misfolded proteins. Neurodegenerative disorders like Alzheimer’s disease, Parkinson’s disease, prion disease, Huntington’s disease, frontotemporal dementia ...
Hoozemans, Jeroen J.M., Scheper, Wiep
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Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases
Nature Reviews Cardiology, 2021Jun Ren +4 more
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Endoplasmic reticulum stress in brain ischemia
International Journal of Neuroscience, 2015Endoplasmic reticulum (ER) stress is an intricate mechanism that mediates numerous responses during brain ischemia, thus being essential to determine the fate of neurons. In recent years, studies of the mechanisms of brain ischemic injury have centered on ER stress, glutamate excitotoxicity, dysfunction of mitochondria, inflammatory reactions, calcium ...
Yingchao Su, Feng Li
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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Science, 2004Umut Özcan +9 more
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