Results 101 to 110 of about 9,566 (262)
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, Volume 66, Issue 5, Page 222-242, June 2025.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source
YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity [PDF]
, 2017 As a typical endoribonuclease, YoeB mediates cellular adaptation in diverse bacteria by degrading mRNAs on its activation. Although the catalytic core of YoeB is thought to be identical to well-studied nucleases, this enzyme specifically targets mRNA ...
Chen, Yun +6 more
core
Structure and Function of PRRSV nsp11 Endoribonuclease
DEStech Transactions on Biology and Health, 2018 Endoribonuclease (NendoU) is conserved and plays essential roles in viral life cycle among all nidoviruses. Porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 11 (nsp11) is shown to have NendoU activity and its multifunctions have been demonstrated, such as processing RNA, suppressing innate immunity system of infected ...
Zhong-Zhou Chen, Wei Wu, Manfeng Zhang
openaire +3 more sources
RETRACTED: The RasGAP-associated endoribonuclease G3BP assembles stress granules [PDF]
The Journal of Cell Biology, 2003 Stress granules (SGs) are formed in the cytoplasm in response to various toxic agents, and are believed to play a critical role in the regulation of mRNA metabolism during stress. In SGs, mRNAs are stored in an abortive translation initiation complex that can be routed to either translation initiation or degradation.
Jamal Tazi +6 more
openaire +3 more sources
A synthetic library of RNA control modules for predictable tuning of gene expression in yeast [PDF]
, 2011 Advances in synthetic biology have resulted in the development of genetic tools that support the design of complex biological systems encoding desired functions.
Babiskin, Andrew H. +1 more
core +4 more sources
Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.ABSTRACT Xylella fastidiosa (Xf) is a Gram‐negative bacterial plant pathogen responsible for severe diseases in a variety of economically important crops. A critical aspect of its virulence is the production of extracellular vesicles (EVs). In this study, we discovered that DNA‐binding proteins and nonribosomal RNA‐binding proteins are abundant in the ...
Alessa Ruf +9 more
wiley +1 more source
Controlling mRNA stability and translation with the CRISPR endoribonuclease Csy4 [PDF]
RNA, 2015 The bacterial CRISPR endoribonuclease Csy4 has recently been described as a potential RNA processing tool. Csy4 recognizes substrate RNA through a specific 28-nt hairpin sequence and cleaves at the 3′ end of the stem. To further explore applicability in mammalian cells, we introduced this hairpin at various locations in mRNAs derived from reporter ...
William F. Marzluff +5 more
openaire +3 more sources
Functional implications of hexameric dynamics in SARS‐CoV‐2 Nsp15
Protein Science, Volume 34, Issue 6, June 2025.Abstract SARS‐CoV‐2, the virus responsible for the COVID‐19 pandemic, has undergone continuous evolution, leading to the emergence of variants with altered transmissibility and immune evasion. For the non‐structural proteins (Nsps) of SARS‐CoV‐2, there are limited structural analyses of their naturally occurring mutations.
Manashi Sonowal +18 more
wiley +1 more source
Plant RNases T2, but not Dicer-like proteins, are major players of tRNA-derived fragments biogenesis
Nucleic Acids Research, 2018 RNA fragments deriving from tRNAs (tRFs) exist in all branches of life and the repertoire of their biological functions regularly increases. Paradoxically, their biogenesis remains unclear.
Cyrille Megel +8 more
semanticscholar +1 more source