Results 81 to 90 of about 6,435 (206)
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions [PDF]
, 2011 Prokaryotes have evolved multiple versions of an RNA-guided adaptive immune system that targets foreign nucleic acids. In each case, transcripts derived from clustered regularly interspaced short palindromic repeats (CRISPRs) are thought to selectively ...
Barendregt, Arjan +10 more
core +4 more sources
Processing Endoribonucleases and mRNA Degradation in Bacteria [PDF]
Journal of Bacteriology, 2002 Volume 184, no. 17, p. 4645-4657, 2002. Page 4647, column 1, lines 42-45: The sentence should read “For example, one message in the T7 early polycistronic mRNA, as well as a few late messages, yields increased protein from RNase III cleavage while the others are not affected by such cleavages (41).”
openaire +3 more sources
Molecular Oncology, Volume 20, Issue 4, Page 877-893, April 2026.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection
EMBO ReportsTo globally profile circRNAs, we employ RNA-Sequencing paired with chimeric junction analysis for alpha-, beta-, and gamma-herpesvirus infection. We find circRNAs are, as a population, resistant to host shutoff. We validate this observation using ectopic
Sarah E Dremel +7 more
doaj +1 more source
RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load. [PDF]
, 2015 The review intends to present and recapitulate the current knowledge on the roles and importance of regulatory RNAs, such as microRNAs and small interfering RNAs, RNA binding proteins and enzymes processing RNAs or activated by RNAs, in cells infected by
Massimo Mallardo, +2 more
core +1 more source
Advanced Science, Volume 13, Issue 19, 2 April 2026.We present a novel DNA vaccine platform featuring intrinsic, non‐targeting dsRNA that significantly enhances immune responses by activating the regulated IRE1‐dependent decay‐RIG‐I signaling pathway. This research elucidates a previously uncharacterized mechanism for dsRNA‐mediated innate immune activation.
Min‐Syuan Huang +10 more
wiley +1 more source
Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli [PDF]
, 2013 BACKGROUND: Bacterial toxin-antitoxin (TA) systems are formed by potent regulatory or suicide factors (toxins) and their short-lived inhibitors (antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons.
Niilo Kaldalu +3 more
core +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng +6 more
wiley +1 more source
A synthetic library of RNA control modules for predictable tuning of gene expression in yeast [PDF]
, 2011 Advances in synthetic biology have resulted in the development of genetic tools that support the design of complex biological systems encoding desired functions.
Babiskin, Andrew H. +1 more
core +4 more sources
Resurrecting the Activity of the RNA Subunit of Human RNase P
ChemBioChem, Volume 27, Issue 6, 27 March 2026.The catalytic RNA (H1 RNA) of the human nuclear tRNA processing enzyme RNase P has >105‐fold lower activity in the absence of its 11 protein cofactors than bacterial RNase P RNAs. By introducing mutations toward the bacterial consensus into its catalytic domain, a two and fivefold activity enhancement could be achieved by changes in the P4‐19/4 region ...
Dan Li +2 more
wiley +1 more source