Results 81 to 90 of about 5,581 (192)

SARS‐CoV‐2 and Cancer Biology: Exploring the Mechanistic Links

Cancer Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background Five years after the emergence of SARS‐CoV‐2 and the declaration of the COVID‐19 pandemic, the long‐term implications of COVID‐19 for cancer biology remain incompletely understood. Beyond the major disruptions in cancer screening, diagnosis, and treatment observed worldwide, increasing attention has focused on whether SARS‐CoV‐2 ...
Andrea Orue, Alejandro Cornejo, Héctor Rafael Rangel   +2 more
wiley   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

RNase J is involved in the 5′-end maturation of 16S rRNA and 23S rRNA in Sinorhizobium meliloti [PDF]

, 2009
Sinorhizobium meliloti harbours genes encoding orthologs of ribonuclease (RNase) E and RNase J, the principle endoribonucleases in Escherichia coli and Bacillus subtilis, respectively. To analyse the role of RNase J in S. meliloti, RNA from a mutant with
Evguenieva-Hackenberg, Elena, Madhugiri, Ramakanth   +1 more
core   +1 more source

Protein Homeostasis and Mitochondrial Quality Control in Neurodegeneration

WIREs Mechanisms of Disease, Volume 18, Issue 4, July/August 2026.
Quality control pathways form an integrated proteostasis–mitochondrial quality control axis that maintains mitochondrial and cellular homeostasis. Failure of this coordinated network drives neuronal decline and contributes to neurodegeneration. ABSTRACT Quality control (QC) processes include a network of cellular pathways that prevent the accumulation ...
Rosa Di Lorenzo, Rola S. Zeidan, Riccardo Calvani, Vito Pesce, Emanuele Marzetti, Anna Picca   +5 more
wiley   +1 more source

Structural basis for human mitochondrial tRNA maturation

Nature Communications
The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise excision of tRNAs by the mitochondrial endoribonucleases (mt-RNase), P and Z,
Vincent Meynier, Steven W. Hardwick, Marjorie Catala, Johann J. Roske, Stephanie Oerum, Dimitri Y. Chirgadze, Pierre Barraud, Wyatt W. Yue, Ben F. Luisi, Carine Tisné   +9 more
doaj   +1 more source

Circular RNAs–Stress Granule Interplay Drives Aging‐Related Proteostasis Loss

Aging Cell, Volume 25, Issue 7, July 2026.
Ribonuclease K (RNASEK) maintains ribostasis by degrading circular RNAs (circRNAs) in young cells, enabling functional stress granules (SG) and proper RNA‐protein metabolism for healthy aging and longevity. In aged cells, reduced RNASEK activity causes circRNA accumulation in SG, disrupting ribostasis and proteostasis, leading to cellular dysfunction ...
José M. Izquierdo
wiley   +1 more source

Broad-specificity endoribonucleases and mRNA degradation in Escherichia coli

, 1992
Crude extracts from Escherichia coli were screened for any broad-specificity endoribonuclease after the cell proteins were fractionated by size. In a mutant lacking the gene for RNase I (molecular mass, 27,156 Da), the only such activities were also in ...
Sunil Kumar Srivastava, Vincent J. Cannistraro, David Kennell   +2 more
core  

Targeted RNA knockdown by crRNA guided Csm in zebrafish

, 2017
RNA interference (RNAi) is a powerful experimental tool for RNA knockdown, but not all organisms are amenable. Here, we provide a “proof of principle” demonstration that CRISPR endoribonucleases can be used for programmable mRNA transcript degradation ...
Gintautas Tamulaitis, Agnieszka Kolano, Thomas Fricke, Matthias Bochtler, Michal Pastor, Virginijus Siksnys, Dalia Smalakyte   +6 more
core   +1 more source

Investigating the 3' RNA Phosphodiesterase and 3'-5' Exoribonuclease Activities of APE1. [PDF]

, 2013
Messenger RNA degradation is a major control point in determining the abundance of mRNA, and hence in the regulation of gene expression. Until recently, endoribonucleases, enzymes that cleave the phosphodiester bond within a polynucleotide chain, have ...

core   +1 more source

Visual Evidence for the Recruitment of Four Enzymes with RNase Activity to the Bacillus subtilis Replication Forks

Cells
Removal of RNA/DNA hybrids for the maturation of Okazaki fragments on the lagging strand, or due to misincorporation of ribonucleotides by DNA polymerases, is essential for all types of cells. In prokaryotic cells such as Escherichia coli, DNA polymerase
Rebecca Hinrichs, Peter L. Graumann
doaj   +1 more source