Results 61 to 70 of about 5,581 (192)

Structure of the MIWI endoribonuclease bound to pachytene piRNAs from mouse testes

Cell Reports
Summary: PIWI-interacting RNAs (piRNAs) guide PIWI endoribonucleases to destroy transposon transcripts, ensuring animal fertility. Here, we report the cryo-electron microscopy structure of the MIWI-pachytene piRNA complex isolated from mouse testes.
Nicole Raad, Carmen Fernandez-Rodriguez, Radha Raman Pandey, Inayathulla Mohammed, Emiko Uchikawa, Fabienne Burger, David Homolka, Ramesh S. Pillai   +7 more
doaj   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts

BMC Plant Biology, 2010
Background Post transcriptional gene silencing (PTGS) is a mechanism harnessed by plant biologists to knock down gene expression. siRNAs contribute to PTGS that are synthesized from mRNAs or viral RNAs and function to guide cellular endoribonucleases to ...
Verchot Jeanmarie, Ye Changming, Nguyen Alien, Silva Asitha T, Moon Joong   +4 more
doaj   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Phylogenetic Analysis of the Endoribonuclease Dicer Family

PLoS ONE, 2014
Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level. Dicers are conserved from basal metazoans to higher metazoans and contain a number of functional domains that interact with dsRNA.
Zeqian Gao, Miao Wang, David Blair, Yadong Zheng, Yongxi Dou   +4 more
openaire   +5 more sources

Characterization of Echinostoma cinetorchis endoribonuclease, RNase H [PDF]

The Korean Journal of Parasitology, 2017
Echinostoma cinetorchis is an oriental intestinal fluke causing significant pathological damage to the small intestine. The aim of this study was to determine a full-length cDNA sequence of E. cinetorchis endoribonuclease (RNase H; EcRNH) and to elucidate its molecular biological characters.
Lim, Sung-Bin, Cha, Seok Ho, Jegal, Seung, Jun, Hojong, Park, Seo Hye, Jeon, Bo-Young, Pak, Jhang Ho, Bakh, Young Yil, Kim, Tong-Soo, Lee, Hyeong-Woo   +9 more
openaire   +2 more sources

Dual IRE1 targets: Determinants of the cell fate?

The FEBS Journal, EarlyView.
IRE1 is an ER stress sensor that restores protein homeostasis through two signaling activities: XBP1s, which upregulates its target gene expression or RIDD which downregulates its target transcripts. We recently identified Dual IRE1 Targets (DIT) which are modulated by both XBP1s and RIDD activities.
Eva Billat, Léane Legrand, Tony Avril, Elodie Lafont   +3 more
wiley   +1 more source

Investigation of the impact of endoribonucleases on bacteriophage T4 early transcripts. [PDF]

, 2013
Phage T4 has developed a complex mechanism of ribonucleases control, which needs yet to be investigated. Apart from the impact of endoribonuclease RegB, no other effects of Escherichia coli- or phage-encoded proteins are known to be involved in the ...
Strazdaitė Žielienė, Živilė,
core  

Nucleases and Their Inhibitors: Exploring Biological Roles, Industrial Applications, and Challenges in Heterologous Expression

Biotechnology Journal, Volume 21, Issue 9, September 2026.
Graphical Abstract and Lay Summary Intracellular nucleases, depicted as blue circles in a nucleosome, hydrolyze phosphodiester bonds, repair damaged DNA using DNA base excision repair (BER), mismatch repair (MMR), and homologous recombination (HR), and are involved in DNA replication.
Wian Vermeulen, Anton Du Preez van Staden, Leon M. T. Dicks   +2 more
wiley   +1 more source

Base-specific ribonucleases potentially involved in heterogeneous nuclear RNA processing and poly(A) metabolism [PDF]

, 1984
Polyadenylation and splicing of heterogeneous nuclear RNA, two crucial steps in mRNA processing, are apparently enzymically mediated processes. This contribution summarizes the properties and the presumed functions of the known poly(A) catabolic enzymes (
Müller, Werner E.G., Bachmann, Michael, Rudolf Messer, Schröder, Heinz C., Michael Bachmann, Heinz C. Schröder, Werner E.G. Müller, Messer, Rudolf   +7 more
core   +1 more source