Results 61 to 70 of about 6,435 (206)

Quorum Sensing Extracellular Death Peptides Enhance the Endoribonucleolytic Activities of Mycobacterium tuberculosis MazF Toxins

mBio, 2018
mazEF is a toxin-antitoxin module located on chromosomes of most bacteria. MazF toxins are endoribonucleases antagonized by MazE antitoxins. Previously, we characterized several quorum sensing peptides called "extracellular death factors" (EDFs).
Akanksha Nigam, Sathish Kumar, Hanna Engelberg-Kulka   +2 more
doaj   +1 more source

Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]

, 2009
A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T., Boone, Charles, Brost, Renee L., Costanzo, Michael, Ozanick, Sarah G., Wang, Xuying   +5 more
core   +1 more source

Community proteogenomics reveals the systemic impact of phosphorus availability on microbial functions in tropical soil. [PDF]

, 2018
Phosphorus is a scarce nutrient in many tropical ecosystems, yet how soil microbial communities cope with growth-limiting phosphorus deficiency at the gene and protein levels remains unknown.
Guo, Xuan, Hazen, Terry C, Li, Zhou, Mayes, Melanie A, Pan, Chongle, Paša-Tolić, Ljiljana, Song, Yang, Tfaily, Malak M, Tringe, Susannah G, Turner, Benjamin L, Wright, S Joseph, Yao, Qiuming   +11 more
core   +1 more source

Biogenesis of TNF‐α‐insights into proteostasis and inflammation

The FEBS Journal, EarlyView.
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar, Céline Philippe, Eric Chevet, Jiří Zahradník   +3 more
wiley   +1 more source

Structure of the MIWI endoribonuclease bound to pachytene piRNAs from mouse testes

Cell Reports
Summary: PIWI-interacting RNAs (piRNAs) guide PIWI endoribonucleases to destroy transposon transcripts, ensuring animal fertility. Here, we report the cryo-electron microscopy structure of the MIWI-pachytene piRNA complex isolated from mouse testes.
Nicole Raad, Carmen Fernandez-Rodriguez, Radha Raman Pandey, Inayathulla Mohammed, Emiko Uchikawa, Fabienne Burger, David Homolka, Ramesh S. Pillai   +7 more
doaj   +1 more source

Novel specificity of an endoribonuclease of yeast [PDF]

FEBS Letters, 1986
Investigations of the cleavage specificity of a cyclizing endoribonuclease of yeast show that it hydrolyzes Y‐A bonds of single‐stranded regions of RNA and that oligonucleotides are hydrolyzed poorly. The stringent specificity of the enzyme suggests that it may be useful for generating specific fragments of polyribonucleotides.
openaire   +2 more sources

Turkey Coronavirus Non-Structure Protein NSP15 – An Endoribonuclease [PDF]

Intervirology, 2008
Turkey coronavirus (TCoV) polyprotein was predicted to be cleaved into 15 non-structural proteins (nsp2 to nsp16), but none of these nsps have been characterized. TCoV nsp15 consists of 338 residues and shares 40% sequence similarity to U-specific <i>Nidovirales</i> endoribonuclease (NendoU) of severe acute respiratory syndrome coronavirus.
Jianzhong, Cao, Ching-Ching, Wu, Tsang Long, Lin   +2 more
openaire   +2 more sources

Molecular Signatures of Peripheral and Central Dental Pulp Subpopulations in Response to Streptococcus mutans: A Bulk RNA‐Seq Analysis

International Endodontic Journal, EarlyView.
ABSTRACT Aim The dental pulp is an immunologically active tissue that responds dynamically to cariogenic challenge. Peripheral pulp cells adjacent to dentine encounter bacterial stimuli earlier than cells located in the central pulp. To investigate signalling and immune interactions, this study profiled the transcriptomes of dentine‐adherent cells ...
Sandra Pohl, Maximilian L. Huber, Tobias Akamp, Andreas Rosendahl, Melanie Linnebank, Lea Schreiber, Claudia Gebhard, Nicholas Strieder, Michael Rehli, Wolfgang Buchalla, Matthias Widbiller   +10 more
wiley   +1 more source

Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts

BMC Plant Biology, 2010
Background Post transcriptional gene silencing (PTGS) is a mechanism harnessed by plant biologists to knock down gene expression. siRNAs contribute to PTGS that are synthesized from mRNAs or viral RNAs and function to guide cellular endoribonucleases to ...
Verchot Jeanmarie, Ye Changming, Nguyen Alien, Silva Asitha T, Moon Joong   +4 more
doaj   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, EarlyView.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source