Results 51 to 60 of about 5,581 (192)

Investigating the role of MARF1-like (MFL) endoribonuclease genes in Arabidopsis

, 2023
Green, Pamela J.RNA decay in eukaryotes is mainly carried out by exoribonucleases and endoribonucleases, but the latter have been underappreciated. In metazoan nonsense-mediated mRNA decay (NMD), the endoribonuclease SMG6 cleaves certain mRNAs, leaving ...
Bogdan, Catherine J.
core   +1 more source

Mouse ribonuclease III. cDNA structure, expression analysis, and chromosomal location

BMC Genomics, 2002
Background Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. A human RNase III orthologue has been implicated in
Nicholson Rhonda H, Fortin Kristine R, Nicholson Allen W   +2 more
doaj   +1 more source

Detection of a fourth orbivirus non-structural protein.

PLoS ONE, 2011
The genus Orbivirus includes both insect and tick-borne viruses. The orbivirus genome, composed of 10 segments of dsRNA, encodes 7 structural proteins (VP1-VP7) and 3 non-structural proteins (NS1-NS3).
Mourad Belhouchet, Fauziah Mohd Jaafar, Andrew E Firth, Jonathan M Grimes, Peter P C Mertens, Houssam Attoui   +5 more
doaj   +1 more source

Protective Role of Polydatin Against Vancomycin‐Induced Lung Toxicity via Oxidative Stress, Inflammation, Endoplasmic Reticulum Stress, Apoptosis, and Ferroptosis Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT This study aimed to evaluate whether polydatin (Poly) could eliminate the harmful effects of vancomycin (VCM) on the lungs of rats. Rats were administered VCM (200 mg/kg) and Poly (50 mg/kg), both separately and in combination, for a duration of 7 days.
Serpil Aygörmez, Sefa Küçükler, Selim Çomaklı, Hasan Şimşek, Özge Kandemir, Fatih Mehmet Kandemir, Şaban Maraşlı   +6 more
wiley   +1 more source

Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease

Journal of Biological Chemistry, 2023
The emergence of severe acute respiratory syndrome coronavirus 2, the causative agent of coronavirus disease 2019, has resulted in the largest pandemic in recent history. Current therapeutic strategies to mitigate this disease have focused on the development of vaccines and on drugs that inhibit the viral 3CL protease or RNA-dependent RNA polymerase ...
Jerry Chen, Rabih Abou Farraj, Daniel Limonta, Seyed Amir Tabatabaei Dakhili, Evan M. Kerek, Ashim Bhattacharya, Filip M. Reformat, Ola M. Mabrouk, Benjamin Brigant, Tom A. Pfeifer, Mark T. McDermott, John R. Ussher, Tom C. Hobman, J.N. Mark Glover, Basil P. Hubbard   +14 more
openaire   +2 more sources

Recognition and Cleavage of a Nonstructured CRISPR RNA by Its Processing Endoribonuclease Cas6 [PDF]

, 2013
SummaryClustered regularly interspaced short palindromic repeats (CRISPRs) confer adaptive immunity to prokaryotes through a small RNA-mediated mechanism. Specific endoribonucleases are required by all CRISPR-bearing organisms to process CRISPR RNAs into
Shao, Yaming, Li, Hong
core   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

Quorum Sensing Extracellular Death Peptides Enhance the Endoribonucleolytic Activities of Mycobacterium tuberculosis MazF Toxins

mBio, 2018
mazEF is a toxin-antitoxin module located on chromosomes of most bacteria. MazF toxins are endoribonucleases antagonized by MazE antitoxins. Previously, we characterized several quorum sensing peptides called "extracellular death factors" (EDFs).
Akanksha Nigam, Sathish Kumar, Hanna Engelberg-Kulka   +2 more
doaj   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Activation of an Endoribonuclease by Non-intein Protein Splicing [PDF]

Journal of Biological Chemistry, 2016
The Chlamydomonas reinhardtii chloroplast-localized poly(A)-binding protein RB47 is predicted to contain a non-conserved linker (NCL) sequence flanked by highly conserved N- and C-terminal sequences, based on the corresponding cDNA. RB47 was purified from chloroplasts in association with an endoribonuclease activity; however, protein sequencing failed ...
Stephen J, Campbell, David B, Stern
openaire   +2 more sources