Results 71 to 80 of about 6,435 (206)

Intrinsic sequence specificity of the Cas1 integrase directs new spacer acquisition [PDF]

, 2015
The adaptive prokaryotic immune system CRISPR-Cas provides RNA-mediated protection from invading genetic elements. The fundamental basis of the system is the ability to capture small pieces of foreign DNA for incorporation into the genome at the CRISPR ...
Arslan, Babu, Barrangou, Beloglazova, Brinkers, Chow, Delelis, Diez-Villasenor, Dillingham, Fineran, Gerton, Goren, Hagerman, Heler, Hutton, Kunin, Lemak, Levy, Liu, Makarova, Nam, Niewoehner, Nuñez, Nuñez, Ramsden, Savilahti, Shmakov, Sorek, Swarts, van der Oost, Wei, Wiedenheft, Yosef, Yosef, Zhang   +34 more
core   +4 more sources

Endoribonucleases associated with RNAs in chick embryos

FEBS Letters, 1979
proteins in hemopoietic rat cells were reported to have RNase activities [ 121. Similarly, an endogeneous endoribonucleolytic activity was found in the 50 S ribosomal subunit of Eschenihia coli [ 131. This paper describes the existence of a RNA-bound cytoplasmic endoribonuclease in chick embryo.
Denoya, Claudio D., Scodeller, Eduardo A., La torre, José L.   +2 more
openaire   +2 more sources

A Novel Endoribonuclease, RNase LS, in Escherichia coli [PDF]

Genetics, 2005
Abstract The dmd gene of bacteriophage T4 is required for the stability of late-gene mRNAs. When this gene is mutated, late genes are globally silenced because of rapid degradation of their mRNAs. Our previous work suggested that a novel Escherichia coli endonuclease, RNase LS, is responsible for the rapid degradation of mRNAs.
Yuichi, Otsuka, Tetsuro, Yonesaki
openaire   +2 more sources

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, EarlyView.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

A novel arabinose-inducible genetic operation system developed for Clostridium cellulolyticum [PDF]

, 2015
Background: Clostridium cellulolyticum and other cellulolytic Clostridium strains are natural producers of lignocellulosic biofuels and chemicals via the consolidated bioprocessing (CBP) route, and systems metabolic engineering is indispensable to meet
Gu-Zhen Cui, Jie Zhang, Qiu Cui, Ya-Jun Liu   +3 more
core   +1 more source

Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque, Aymeric Jacquemin, Delphine Girlich, Rémy A. Bonnin, Laurent Dortet   +4 more
wiley   +1 more source

RNA Sequencing Identifies New RNase III Cleavage Sites in Escherichia coli and Reveals Increased Regulation of mRNA

mBio, 2017
Ribonucleases facilitate rapid turnover of RNA, providing cells with another mechanism to adjust transcript and protein levels in response to environmental conditions. While many examples have been documented, a comprehensive list of RNase targets is not
Gina C. Gordon, Jeffrey C. Cameron, Brian F. Pfleger   +2 more
doaj   +1 more source

In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus [PDF]

, 2013
Clustered regularly interspaced short palindromic repeats (CRISPR)-encoded immunity in Type I systems relies on the Cascade (CRISPR-associated complex for antiviral defence) ribonucleoprotein complex, which triggers foreign DNA degradation by an ...
Giedrius Gasiunas, Ishino Y, Mark J Dickman, Mulepati S, Philippe Horvath, Rodolphe Barrangou, Sakharam P Waghmare, Tomas Sinkunas, Virginijus Siksnys   +8 more
core   +2 more sources

Unusual Cytology Features of A DICER1‐Mutated Thyroid Nodule: Raising Awareness of A Potential Diagnostic Pitfall During Fine Needle Aspiration

Cytopathology, Volume 37, Issue 3, Page 300-303, May 2026.
This article describes the unusual cytology features of a DICER1‐mutated thyroid nodule. Fine needle aspiration revealed predominantly cell debris/degenerated cells and rare viable follicular cells with mild cytologic atypia. Surgical resection revealed a nodule with nearly complete infarction, which is one specific feature of DICER1‐mutated thyroid ...
Wenli Dai, Eduardo V. Zambrano, Sabri Yilmaz, Qian Wang   +3 more
wiley   +1 more source