Results 91 to 100 of about 5,581 (192)
Pyrimidine-specific cleavage by an endoribonuclease of Saccharomyces cerevisiae [PDF]
Journal of Bacteriology, 1985 An endoribonuclease with pyrimidine cleavage site specificity was isolated from Saccharomyces cerevisiae. The enzyme had a pH optimum of 6 to 7 and did not require a divalent cation. It was inhibited by 5 X 10(-5) M ethidium bromide, although it appeared to be single strand specific.
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RNA Recognition and Cleavage by the SARS Coronavirus Endoribonuclease
Journal of Molecular Biology, 2006 The emerging disease SARS is caused by a novel coronavirus that encodes several unusual RNA-processing enzymes, including non-structural protein 15 (Nsp15), a hexameric endoribonuclease that preferentially cleaves at uridine residues. How Nsp15 recognizes and cleaves RNA is not well understood and is the subject of this study.
Bhardwaj, Kanchan +4 more
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Role of RNase MRP in Viral RNA Degradation and RNA Recombination
, 2011 RNA degradation, together with RNA synthesis, controls the steady-state level of viral RNAs in infected cells. The endoribonucleolytic cleavage of viral RNA is important not only for viral RNA degradation but for RNA recombination as well, due to the ...
Mark E. Schmitt +3 more
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A Non-Stem-Loop CRISPR RNA Is Processed by Dual Binding Cas6 [PDF]
, 2016 A subclass of recently discovered CRISPR repeat RNA in bacteria contains minimally recognizable structural features that facilitate an unknown mechanism of recognition and processing by the Cas6 family of endoribonucleases.
Henning Urlaub +12 more
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The Roles of Rnt1 and Putative Endoribonucleases in Eukaryotic mRNA Degradation
Endoribonucleases initiate degradation by cleaving RNAs internally. Mutations in these enzymes have been shown to cause diseases such as cancer, developmental disorders, and neurodegenerative diseases. Yet, eukaryotic endoribonucleases have not been well
Notice-Sarpaning, Lee-Ann
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Towards new antituberculotic targets: biochemical characterisation of mycobacterial RNase E/G
European Respiratory Review, 2008 The World Health Organization estimates that each year 3 million people die from tuberculosis (TB) and 8 million people become infected. No new anti-TB drugs have been introduced in the past 30 years, even though their development becomes increasingly ...
Agnes Csanadi +5 more
doaj
Ribonucleases in bacterial toxin–antitoxin systems
, 2013 Toxin-antitoxin (TA) systems are widespread in bacteria and archaea and play important roles in a diverse range of cellular activities. TA systems have been broadly classified into 5 types and the targets of the toxins are diverse, but the most ...
Cook, Gregory M. +8 more
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Post-transcriptional control of virulence gene expression in Staphylococcus aureus
, 2019 International audienceOpportunistic pathogens have to be ready to change life-style whenever the occasion arises, and therefore need to keep tight control over the expression of their virulence factors.
Alexandre Le Scornet +3 more
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VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
, 2013 The highly persistent and often lethal human pathogen, Mycobacterium tuberculosis contains at least 88 toxin–antitoxin genes. More than half of these encode VapC PIN domain endoribonucleases that inhibit cell growth by unknown mechanisms.
Gerdes, Kenn +3 more
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Novel findings on endoribonuclease activity of proteasomes [PDF]
Cell Cycle, 2010 Alexey V, Sorokin, Lev P, Ovchinnikov
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