Results 101 to 110 of about 47,261 (313)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Immuno Magnetic Thermosensitive Liposomes For Cancer Therapy [PDF]

, 2019
The present work describes the encapsulation of the drug doxorubicin (DOX) in immuno paramagnetic thermosensitive liposomes. DOX is the most common chemotherapeutic agent for the treatment of a variety of carcinomas.
Alawak, Mohamad
core   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin

Molecular Therapy: Nucleic Acids, 2019
The therapeutic promise of small-RNA therapeutics is limited, not only by the lack of delivery vehicles, but also by the inability of the small RNAs to reach intracellular compartments where they can be biologically active.
Esteban A. Orellana, Ahmed M. Abdelaal, Loganathan Rangasamy, Srinivasarao Tenneti, Sunghyun Myoung, Philip S. Low, Andrea L. Kasinski   +6 more
doaj   +1 more source

Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response [PDF]

, 2018
Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms.
Hanson, Phyllis I, Köster, Stefan, Mehra, Alka, Mittal, Ekansh, Philips, Jennifer A, Skowyra, Michael L, Tinaztepe, Emir, Uwase, Grace   +7 more
core   +2 more sources

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA

Science Advances, 2022
Quantitative bioassay enables the development of next-generation biodegradable polymeric nanoparticles for in vivo mRNA delivery.
Y. Rui, David R. Wilson, S. Tzeng, Hannah Yamagata, Deepti Sudhakar, M. Conge, C. Berlinicke, D. Zack, Anthony Tuesca, J. Green   +9 more
semanticscholar   +1 more source

Intrinsically Disordered Protein‐Inspired Nanovector‐Based Coacervates for the Direct Cytosolic Transport of Biomacromolecules

Advanced Materials, EarlyView.
Intrinsically disordered protein‐inspired nanovectors (IDP‐NVs) form stable nanocoacervates (NCs) with diverse biomacromolecules. In situ conformational changes confer stability and adaptability to NCs under dynamically changing physiological conditions.
Soyeong Jin, Hyemin Park, Seuk‐Min Ryu, Dagyeong Guk, Jaeeun Lee, Seongeon Jin, Changjoon Keum, Jinyoung Park, Myoung‐Hwan Park, Chaekyu Kim, Hojun Kim, Jaegeun Noh, Kwan Hyi Lee, Ja‐Hyoung Ryu, Youngdo Jeong   +14 more
wiley   +1 more source

Single-cell quantification and dose-response of cytosolic siRNA delivery

Nature Communications, 2023
Endosomal escape and subsequent cytosolic delivery of siRNA therapeutics is inefficient, and quantification is difficult. Here the authors report a confocal microscopy-based method to quantify cytosolic delivery of fluorescently labelled siRNA during ...
Hampus Hedlund, Hampus Du Rietz, Johanna M. Johansson, Hanna C. Eriksson, Wahed Zedan, Linfeng Huang, Jonas Wallin, Anders Wittrup   +7 more
doaj   +1 more source

Poly(amido amine)s as Gene Delivery Vectors: Effects of Quaternary Nicotinamide Moieties in the Side Chains [PDF]

, 2008
To evaluate the effect of quaternary nicotinamide pendant groups on gene delivery properties, a series of poly(amido amine) (co)polymers were synthesized by Michael addition polymerization of N, N-cystaminebisacrylamide with variable ratios of 1-(4 ...
Engbersen, Johan F.J., Feijen, Jan, Hennink, Wim E., Lok, Martin C., Mateos Timoneda, Miguel A.   +4 more
core   +7 more sources

Designing Mesoporous Silica Nanoparticles to Overcome Biological Barriers by Incorporating Targeting and Endosomal Escape

ACS Applied Materials and Interfaces, 2021
The several biological barriers that nanoparticles might encounter when administered to a patient constitute the major bottleneck of nanoparticle-mediated tumor drug delivery, preventing their successful translation into the clinic and reducing their ...
M. Gisbert-Garzarán, D. Lozano, Kotaro Matsumoto, A. Komatsu, M. Manzano, F. Tamanoi, M. Vallet‐Regí   +6 more
semanticscholar   +1 more source