Bio‐Inspired, Zwitterionic Copolymers with Amphiphilic Character
Macromolecular Rapid Communications, EarlyView.Zwitterionic copolymers based on arginine‐derived monomers are produced by xanthate‐supported photo‐iniferter reversible‐addition‐fragmentation chain‐transfer polymerization. Experiments in relevant conditions show that the designed (co)polymers hardly interact with biologically relevant proteins and enzymes such as bovine serum albumine (BSA), fetal ...
Theresa M. Lutz +4 more
wiley +1 more source
Poly(sarcosine) Lipid Synthesis From CO2‐Based Sarcosine‐N‐Carboxyanhydride
Macromolecular Rapid Communications, EarlyView.In this work, we optimize and scale‐up a CO2‐based synthesis of sarcosine‐N‐carboxyanhydride (Sar‐NCA) to the gram scale. The low toxicity and simplicity of the approach make it an attractive alternative to current toxic phosgene‐based approaches. The CO2‐based Sar‐NCA has sufficient purity for controlled polymerization.
Florian T. Kaps +7 more
wiley +1 more source
Dendronized mesoporous silica nanoparticles provide an internal endosomal escape mechanism for successful cytosolic drug release [PDF]
, 2016 Veronika Weiß +10 more
openalex +1 more source
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Cell division responsive peptides for optimized plasmid DNA delivery : the mitotic window of opportunity? [PDF]
, 2014 De Smedt, Stefaan +4 more
core +1 more source
542. The Innate Immune Response to Intravenously Injected Adenoviral Vectors: Role of Endosomal Escape in MAP Kinase Activation and the Cytokine/Chemokine Response [PDF]
, 2010 openalex +1 more source
PROTEOMICS, EarlyView.ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq +6 more
wiley +1 more source
Quantitative Assessment of Endosomal Escape of Various Endocytosed Polymer‐Encapsulated Molecular Cargos upon Photothermal Heating [PDF]
, 2020 Nico Brkovic +5 more
openalex +1 more source
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source