Results 201 to 210 of about 399,723 (294)

Fatty acid 2-hydroxylase facilitates rotavirus uncoating and endosomal escape. [PDF]

Proc Natl Acad Sci U S A
Li E, Zang R, Kawagishi T, Zhang W, Iyer K, Hou G, Zeng Q, Meganck RM, Ross SR, Wang X, Su X, Ding S.   +11 more
europepmc   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Impact of Nanoparticle Stiffness on Endosomal Escape and Signaling Pathways in Cytosolic Delivery. [PDF]

Adv Healthc Mater
Zhang Y, Hui Y, Guo Z, Liu D, Liu Y, Gao H, Zhao CX.   +6 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Cholesterol-dependent control of endosomal escape regulates intracellular trafficking of small interfering RNA therapeutics and interactions with small molecule drugs. [PDF]

J Pharmacol Exp Ther
Tawfik SM, Giang Nguyen LT, Jin J, Armanios B, Zhong XB.   +4 more
europepmc   +1 more source

Distinct Effects of Endosomal Escape and Endosomal Trafficking on Gene Delivery via Electrotransfection [PDF]

Biophysical Journal, 2017
Lisa D. Cervia, Chun-Chi Chang, Liangli Wang, Fan Yuan   +3 more
openaire   +1 more source

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects

bioRxiv
Serena Omo-Lamai, Yufei Wang, Manthan N. Patel, Eno-Obong Essien, Mengwen Shen, Aparajeeta Majumdar, Carolann L. Espy, Jichuan Wu, Breana Channer, Michael Tobin, Shruthi Murali, T. Papp, Rhea Maheshwari, Liuqian Wang, Liam S. Chase, Marco E. Zamora, Mariah L. Arral, O. Marcos-Contreras, J. Myerson, Christopher A. Hunter, Andrew Tsourkas, Vladimir R. Muzykantov, Igor E. Brodsky, Sunny Shin, Kathryn A. Whitehead, P. Gaskill, D.E. Discher, H. Parhiz, J. Brenner   +28 more
semanticscholar   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, Volume 36, Issue 40, 18 May 2026.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Magnetic Resonance Imaging-Based Quantification of Endosomal Escape Using Iron Oxide Nanoparticle-Loaded Lipid Nanoparticles. [PDF]

Adv Healthc Mater
Lee S, Park J, Jung HN, Li S, Lin Z, Im HJ.   +5 more
europepmc   +1 more source