Results 221 to 230 of about 399,723 (294)

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

Hastened Fusion-Dependent Endosomal Escape Improves Activity of Delivered Enzyme Cargo. [PDF]

ACS Cent Sci
Vázquez-Maldonado AL, Chen T, Rodriguez D, Zoltek M, Schepartz A.   +4 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Prolonged gene silencing by combining siRNA nanogels and photochemical internalization [PDF]

, 2010
De Smedt, Stefaan, Demeester, Jo, Hogset, A, Naeye, Broes, Raemdonck, Koen   +4 more
core   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

A new approach for direct visualization of unlabeled lipid nanoparticles for intracellular pathway analysis [PDF]

BIO Web of Conferences
Testa Filippo, Salvioni Lucia, Giustra Marco, Ostroman Irene, Ferrari Beatrice, Duncan Cameron, Colombo Miriam, Fiandra Luisa, Vanacore Giovanni Maria, Prosperi Davide   +9 more
doaj   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, Volume 13, Issue 27, 13 May 2026.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides <i>in vitro</i>. [PDF]

Mol Ther Nucleic Acids
Estupiñán HY, Baladi T, Roudi S, Munson MJ, Bost J, Gustafsson O, Velásquez-Ramírez D, Bhatt DK, Hagey D, Hekman D, Andersson S, Andaloussi SE, Dahlén A.   +12 more
europepmc   +1 more source

Organelle‐Targeted Photosensitizer‐Loaded Nanodiscs for Improved Tumor Photoimmunotherapy

Aggregate, Volume 7, Issue 5, May 2026.
Four organelle‐targeted photosensitizers (PSs) based on pyropheophorbide a (Ppa), which specifically target mitochondria, lysosomes, ER, and nucleus, respectively, were synthesized. These PSs were individually encapsulated into sHDL nanodiscs to improve their stability, biocompatibility, and targeting efficiency.
Yunxue Xu, Wenlong Zeng, Renfa Liu, Zhifei Dai   +3 more
wiley   +1 more source

Accelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction. [PDF]

ACS Appl Mater Interfaces
Weiss S, Decker S, Kugler C, Gómez LB, Fasching H, Benisch D, Alioglu F, Ferencz L, Birkfeld T, Ilievski F, Baumann V, Duran A, Dusinovic E, Follrich N, Milenkovic S, Mihalicokova D, Paunov D, Singeorzan K, Zehetmayer N, Zivanonvic D, Lächelt U, Boersma A, Rülicke T, Sami H, Ogris M.   +24 more
europepmc   +1 more source