Results 241 to 250 of about 399,723 (294)

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Tackling Anticancer Drug Resistance and Endosomal Escape in Aggressive Brain Tumors Using Bioelectronics. [PDF]

ACS Omega
Jain A, Wade P, Stolnik S, Hume AN, Kerr ID, Coyle B, Rawson F.   +6 more
europepmc   +1 more source

Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 5, May 2026.
This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng, Yu‐Xuan Gao, Mei‐Xing Guo, Li‐Ting Wang, Xiao‐Wen Zheng, Yi‐Hao Liao, Ya Li, Jun‐Ping Zhu, Jia‐Ming Wei   +8 more
wiley   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, Volume 22, Issue 26, 8 May 2026.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

A Biomimetic Micro‐Nano System Maximizing ‘Active Transport and Retention’ Effect in Solid Tumors

Small, Volume 22, Issue 25, 4 May 2026.
The Active Transport and Retention (ATR) strategy is realized using a biomimetic micro‐nano system (PG@BAM‐LRC), achieving superior tumor accumulation and efficacy in low‐EPR pancreatic tumors. Platelet (PG)‐derived microcarriers enable tumor‐homing and MMP‐9‐responsive release of nanoliposomes (LRC), while berbamine (BAM) promotes transendothelial ...
Kaiyun Yang, Jiajia Su, Alan J. Davidson, Zimei Wu, Wenli Zhang   +4 more
wiley   +1 more source

Charge-guided masking of a membrane-destabilizing peptide enables efficient endosomal escape for targeted intracellular delivery of proteins. [PDF]

Acta Pharm Sin B
Zhao Y, Jiang H, Chen H, Yu J, Wang L, Zhou W, Du J.   +6 more
europepmc   +1 more source

Nanomicelle‐Based Multi‐mRNA Delivery Promotes Cardiac Repair After Myocardial Infarction

Small Science, Volume 6, Issue 5, May 2026.
Five reparative factors identified during myocardial recovery after treatment with extracellular vesicles derived from human iPS cell‐derived cardiomyocytes were combined into an mRNA cocktail and delivered to infarcted hearts using polyplex nanomicelles.
Kazuma Handa, Takuji Kawamura, Yasunobu Mano, Hideyuki Nakanishi, Lisa Fujimura, Chie Kawai, Akima Harada, Kosuke Torigata, Kenji Miki, Keiji Itaka, Shigeru Miyagawa   +10 more
wiley   +1 more source

Quantifying and Leveraging Interfacial Amine Reactivity in Block Copolymer Nanoparticles for Advanced Material Design

Small Science, Volume 6, Issue 5, May 2026.
Amine‐functionalized block copolymer nanoparticles were synthesized via RAFT‐PISA with rigorous quantification of interfacial amine accessibility. The surface‐reactive amines served as modular handles for postassembly conjugation with fluorescent dyes and thermoresponsive polymers, conferring optical trackability and stimuli‐responsive behaviors ...
Aharon Steffè, Beatrice Rosetti, Stefano Valente, Maria Sbacchi, Federica Battistin, Paolo Tecilla, Pierangelo Gobbo   +6 more
wiley   +1 more source

Entry Without Expression: Internalisation Does Not Predict mRNA Translation for Targeted Lipid Nanoparticles

Small Science, Volume 6, Issue 5, May 2026.
Internalisation of mRNA–lipid nanoparticles (LNPs) into cells does not predict the level of protein expression. We used an internalisation sensor to quantify association, uptake, and mRNA translation of targeted LNPs in human T and B cells. Antibody targeting enhanced cell‐specific association, however receptor‐dependent intracellular processing ...
Cameron H. Smyth, Lara M. Mollé, Victoria McLeod, Moore Z. Chen, Angus P. R. Johnston   +4 more
wiley   +1 more source