Results 251 to 260 of about 399,723 (294)

Swelling, Rupture and Endosomal Escape of Biological Nanoparticles Per Se and Those Fused with Liposomes in Acidic Environment. [PDF]

Pharmaceutics
Ponomareva N, Brezgin S, Karandashov I, Kostyusheva A, Demina P, Slatinskaya O, Bayurova E, Silachev D, Pokrovsky VS, Gegechkori V, Khaydukov E, Maksimov G, Frolova A, Gordeychuk I, Zamyatnin AA, Chulanov V, Parodi A, Kostyushev D.   +17 more
europepmc   +1 more source

Nano‐Enabled Toxicity of Pharmaceutical Excipients

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 3, May/June 2026.
Excipients regarded as safe in bulk form may become toxic once incorporated into nanocarriers. This review raises awareness of nano‐enabled toxicity and highlights analytical tools and safer alternative excipients to support risk‐mitigated nanomedicine development.
Ilaria Polidori, Lena Werner, Andreas Bernkop‐Schnürch   +2 more
wiley   +1 more source

Polymeric carriers in non-viral gene delivery: a study of physicochemical properties and biological activity in human RPE cell line (Polymeeriset kuljettimet geeninsiirrossa: tutkimus fysikaalis-kemiallisista ominaisuuksista ja biologisesta aktiivisuudesta ihmisen retinan pigmentti-epiteelisoluissa) [PDF]

Männistö, Marjo
core  

Enhancing Endosomal Escape and Gene Regulation Activity for Spherical Nucleic Acids. [PDF]

Small
Park J, Evangelopoulos M, Vasher MK, Kudruk S, Ramani N, Mayer V, Solivan AC, Lee A, Mirkin CA.   +8 more
europepmc   +1 more source

Globoside is an essential intracellular factor required for parvovirus B19 endosomal escape in erythroid progenitor cells

Bieri J, Suter C, Caliaro O, Bartetzko S, Bircher C, Ros C.   +5 more
europepmc   +1 more source

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Endolysosomal trapping of therapeutics and endosomal escape strategies

Drug Discovery Today
Internalizing therapeutic molecules or genes into cells and safely delivering them to the target tissue where they can perform the intended tasks is one of the key characteristics of the smart gene/drug delivery vector. Despite much research in this field, endosomal escape continues to be a significant obstacle to the development of effective gene/drug
Aqeel Ahmad, Javed Masood Khan, Bilal Ahamad Paray   +2 more
exaly   +4 more sources

Endosomal escape pathways for delivery of biologicals

Journal of Controlled Release, 2011
Despite continuous improvements in delivery systems, the development of methods for efficient and specific delivery of targeted therapeutic agents still remains an issue in biological treatments such as protein and gene therapy. The endocytic pathway is the major uptake mechanism of cells and any biological agents, such as DNA, siRNA and proteins ...
Amir K Varkouhi, Gert Storm, Hidde J Haisma   +2 more
exaly   +6 more sources

Unravelling the endosomal escape of pH-responsive nanoparticles using the split luciferase endosomal escape quantification assay

Biomaterials Science
Our work demonstrates the adaptation of a highly versatile split-luciferase endosomal escape quantification (SLEEQ) assay to better understand the endosomal escape efficiency of pH-responsive nanoparticles by tuning the HiBiT linker chemistry.
Umeka Nayanathara, Fan Yang, Changhe Zhang, Yufu Wang, Bruna Rossi Herling, Samuel A. Smith, Maximilian A. Beach, Angus P. R. Johnston, Georgina K. Such   +8 more
openaire   +3 more sources

Get out or die trying: Peptide- and protein-based endosomal escape of RNA therapeutics

Advanced Drug Delivery Reviews, 2023
RNA therapeutics offer great potential to transform the biomedical landscape, encompassing the treatment of hereditary conditions and the development of better vaccines.
Michael Bürger, Jean-Christophe Leroux   +1 more
exaly   +2 more sources

Core mission: mRNA endosomal escape

Nature Reviews Chemistry
Sihan Xiong, Chuang Liu
openaire   +3 more sources