Results 231 to 240 of about 399,723 (294)
From phagocytosis to metaforosis: calcineurin's deadly role in innate processing of fungi [PDF]
, 2018 Armstrong-James, D +3 more
core +3 more sources
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Multitissue targeting and nanodelivery strategies centred on ADP‐ribosylation factor 6 for type 2 diabetes and insulin resistance. Abstract Disorders of glucose metabolism, particularly type 2 diabetes and obesity, remain major therapeutic challenges because they involve dysfunction across multiple tissues, including pancreatic β‐cells, peripheral ...
Yangyang Wang +3 more
wiley +1 more source
A Serum Resistant Polymer with Exceptional Endosomal Escape and mRNA Delivery Efficacy for CRISPR Gene Therapy. [PDF]
Adv Sci (Weinh)Lv J +8 more
europepmc +1 more source
Drug Development Research, Volume 87, Issue 3, May 2026.ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood‐brain barrier (BBB). Although recent studies have separately explored STING agonism, microglial reprogramming, and nanocarrier‐based drug delivery, an ...
Mohamed S. Nafie +2 more
wiley +1 more source
Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System
European Journal of Immunology, Volume 56, Issue 5, May 2026.Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami +2 more
wiley +1 more source
In vivo CAR therapies: Turning the patient into their own CAR factory
HemaSphere, Volume 10, Issue 5, May 2026.Abstract Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo CAR approaches
François Vilcot +3 more
wiley +1 more source
A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye
Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro +8 more
wiley +1 more source
<i>In vivo</i> demonstration of enhanced mRNA delivery by cyclic disulfide-containing lipid nanoparticles for facilitating endosomal escape. [PDF]
RSC Med ChemKimura S +9 more
europepmc +1 more source
Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.ABSTRACT Circulating extracellular vesicles (EVs) offer a promising source of non‐invasive biomarkers for congenital disease diagnostics but robust assays for their detection are lacking. We used a rodent pregnancy model as a proxy for a prenatal diagnostics assay to test whether we could detect a difference in EV tetraspanin display between pregnant ...
Petra Adamova +3 more
wiley +1 more source
MedComm, Volume 7, Issue 5, May 2026.Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li +9 more
wiley +1 more source