Results 301 to 310 of about 47,261 (313)

Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.

Small
Treatments for cancer that incorporate small interfering RNA (siRNA) to target iron-dependent ferroptosis are thought to be highly promising. However, creating a reliable and clinically feasible siRNA delivery system continues to be a major obstacle in ...
Yuanyuan Liu, Fengyang He, Longming Chen, Yahan Zhang, Han Zhang, Junhai Xiao, Qingbin Meng   +6 more
semanticscholar   +1 more source

Endolysosomal trapping of therapeutics and endosomal escape strategies

Drug Discovery Today
Internalizing therapeutic molecules or genes into cells and safely delivering them to the target tissue where they can perform the intended tasks is one of the key characteristics of the smart gene/drug delivery vector. Despite much research in this field, endosomal escape continues to be a significant obstacle to the development of effective gene/drug
Aqeel, Ahmad, Javed Masood, Khan, Bilal Ahamad, Paray, Khalid, Rashid, Ashib, Parvez   +4 more
openaire   +2 more sources

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

Nanoscale, 2014
Gene therapy with siRNA is a promising biotechnology to treat cancer and other diseases. To realize siRNA-based gene therapy, a safe and efficient delivery method is essential. Nanoparticle mediated siRNA delivery is of great importance to overcome biological barriers for systemic delivery in vivo.
openaire   +2 more sources

Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery.

Current Medicinal Chemistry
This review article discusses the challenges of delivering cargoes to the cytoplasm, for example, proteins, peptides, and nucleic acids, and the mechanisms involved in endosomal escape.
Sakshi Soni, S. K. Kori, Priyanshu Nema, Arun K. Iyer, Vandana Soni, S. Kashaw   +5 more
semanticscholar   +1 more source

Endosomal acidic pH-induced conformational changes of a cytosol-penetrating antibody mediate endosomal escape

Journal of Controlled Release, 2016
Endosomal escape after endocytosis is a critical step for protein-based agents to exhibit their effects in the cytosol of cells. However, antibodies internalized into cells by endocytosis cannot reach the cytosol due to their inability to escape from endosomes.
Ji-Sun, Kim, Dong-Ki, Choi, Ju-Yeon, Shin, Seung-Min, Shin, Seong-Wook, Park, Hyun-Soo, Cho, Yong-Sung, Kim   +6 more
openaire   +2 more sources

Tracking the Endosomal Escape of Nanoparticles in Live Cells Using a Triplex‐Forming Oligonucleotide

Advanced Functional Materials
Nanoparticle‐mediated intracellular delivery of oligonucleotides is a complex phenomenon that depends on the architecture and the intracellular trafficking of the engineered nanoparticles. Unravelling the molecular arrangements of oligonucleotides within
S. K. Bhangu, Liviana Mummolo, S. Fernandes, Alessia Amodio, Agata Radziwon, Brendan P. Dyett, Marco Savioli, Nitin Mantri, Christina Cortez‐Jugo, Frank Caruso, Francesca Cavalieri   +10 more
semanticscholar   +1 more source

Beyond chloroquine: Cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics.

Current Opinion in Chemical Biology
Nucleic acid (NA) therapeutics have the potential to treat or prevent a myriad of diseases but generally require cytosolic delivery to be functional. NA drugs are therefore often encapsulated into delivery systems that mediate effective endocytic uptake ...
Aliona Debisschop, Bram Bogaert, Cristina Muntean, S. D. De Smedt, K. Raemdonck   +4 more
semanticscholar   +1 more source

Regulating mRNA endosomal escape through lipid rafts: A review

International Journal of Pharmaceutics
Messenger RNA (mRNA) therapeutics, enabled by lipid nanoparticles (LNPs) delivery systems, have revolutionized modern medicine by facilitating the delivery of genetic cargo to target cells. However, the efficient release of mRNA from LNPs within the endosomal pathways into the cytosol remains a major bottleneck in this field. Revisiting the formulation
Xinxin, Wang, Xin, Shi, Ruifeng, Wang
openaire   +2 more sources

Second Generation PS‐ASO Internalization and Endosomal Escape

The FASEB Journal, 2017
Phosphorothioate (PS)‐modified antisense oligonucleotides (ASOs) have been extensively investigated over the past few decades as therapeutic agents. Clearance of ASOs by liver and kidney greatly affect their efficacy for gene knockdown or modifications on the RNA level.
Colton Miller, Andrew Egger, Bri Kellar, Blake Hass, Punit P. Seth, Edward N. Harris   +5 more
openaire   +1 more source

Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects.

Journal of Controlled Release, 2023
Xueying Tang, Jiashuo Zhang, Dezhi Sui, Qiongfen Yang, Tianyu Wang, Zihan Xu, Xiaoya Li, Xin Gao, Xinyang Yan, Xinrong Liu, Yanzhi Song, Yihui Deng   +11 more
semanticscholar   +1 more source