Results 11 to 20 of about 24,168 (116)
Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy* [PDF]
Journal of Biological Chemistry, 2016 hsc-70 (HSPA8) is a cytosolic molecular chaperone, which plays a central role in cellular proteostasis, including quality control during protein refolding and regulation of protein degradation.
Erik Zuiderweg +2 more
exaly +4 more sources
Starvation induces rapid degradation of selective autophagy receptors by endosomal microautophagy [PDF]
Journal of Cell Biology, 2018 It is not clear to what extent starvation-induced autophagy affects the proteome on a global scale and whether it is selective. In this study, we report based on quantitative proteomics that cells during the first 4 h of acute starvation elicit lysosomal
Steingrim Svenning +2 more
exaly +4 more sources
Microautophagy: definition, classification, and the complexity of the underlying mechanisms [PDF]
AutophagyRecently, rapid progress in the field of microautophagy (MI-autophagy) revealed the existence of multiple subtypes that differ in both intracellular membrane dynamics and molecular mechanisms.
Masanori Izumi +2 more
exaly +3 more sources
Lipid droplets in stress protection: distinct mechanisms of lipid droplet microautophagy
Autophagy Reports, 2022 Lipid droplets (LDs) are organelles that function as sites for lipid storage. LDs have also been implicated in the cellular response to proteotoxic or lipotoxic stress as sites for sequestering dysfunctional or excess proteins or lipids, and targeting ...
Pin-Chao Liao, Liza A. Pon
doaj +2 more sources
PLoS Genetics, 2019 The ubiquitin-proteasome system regulates numerous cellular processes and is central to protein homeostasis. In proliferating yeast and many mammalian cells, proteasomes are highly enriched in the nucleus.
Jianhui Li +4 more
doaj +2 more sources
Assessment of mammalian endosomal microautophagy. [PDF]
Methods Cell Biol, 2021 Krause GJ, Cuervo AM.
europepmc +2 more sources
ESCRT machinery plays a role in microautophagy in yeast
BMC Molecular and Cell Biology, 2020 Background Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein kinase.
Shamsul Morshed +2 more
doaj +1 more source
The endosomal sorting complex required for transport repairs the membrane to delay cell death
Frontiers in Oncology, 2022 The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang +5 more
doaj +1 more source
Microautophagy of cytosolic proteins by late endosomes. [PDF]
, 2011 Autophagy delivers cytosolic components to lysosomes for their degradation. The delivery of autophagic cargo to late endosomes for complete or partial degradation has also been described.
Scharf B +9 more
core +3 more sources
Frontiers in Molecular Neuroscience, 2020 Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease (AD), Frontotemporal Dementia (FTD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), and many others where microtubule-associated protein tau ...
Shanya Jiang, Kiran Bhaskar
doaj +1 more source