Molecular interplays of the Entamoeba histolytica endosomal sorting complexes required for transport during phagocytosis [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Entamoeba histolytica, the causative agent of human amoebiasis, exhibits a continuous membrane remodelling to exert its virulence properties. During this dynamic process, the Endosomal Sorting Complexes Required for Transport (ESCRT) machinery is a key ...
Cecilia Bañuelos +5 more
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The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. [PDF]
Mol Membr Biol, 2014 The endosomal sorting complexes required for transport (ESCRT) are needed for three distinct cellular functions in higher eukaryotes: (i) Multivesicular body formation for the degradation of transmembrane proteins in lysosomes, (ii) midbody abscission ...
Mattissek C, Teis D.
europepmc +5 more sources
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. [PDF]
J Biol Chem, 2012 Background: LIP5 helps regulate the membrane fission and recycling activities of the ESCRT pathway. Results: Biochemical and structural studies reveal how LIP5 binds different ESCRT-III proteins.
Skalicky JJ +8 more
europepmc +6 more sources
Coding Mutations in Vacuolar Protein-Sorting 4 AAA+ ATPase Endosomal Sorting Complexes Required for Transport Protein Homologs Underlie bc-2 and New bc-4 Gene Conferring Resistance to Bean Common Mosaic Virus in Common Bean. [PDF]
Front Plant Sci, 2021 Bean common mosaic virus (BCMV) is a major disease in common bean (Phaseolus vulgaris L.). Host plant resistance is the most effective strategy to minimize crop damage against BCMV and the related Bean common mosaic necrosis virus (BCMNV).
Soler-Garzón A, McClean PE, Miklas PN.
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BAG3 Regulation of RAB35 Mediates the Endosomal Sorting Complexes Required for Transport/Endolysosome Pathway and Tau Clearance [PDF]
Biological Psychiatry, 2021 Background Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer’s disease (AD). Emerging studies implicate impairment of the endosome-lysosome pathway as a significant factor in the ...
Heng Lin +7 more
semanticscholar +3 more sources
When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease
Swiss Medical Weekly, 2016 Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell ...
Victor Alfred, Thomas Vaccari
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ESCRT Machinery in HBV Life Cycle: Dual Roles in Autophagy and Membrane Dynamics for Viral Pathogenesis [PDF]
CellsThe endosomal sorting complexes required for transport (ESCRT) comprise a fundamental cellular machinery with remarkable versatility in membrane remodeling.
Jia Li, Reinhild Prange, Mengji Lu
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Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
Frontiers in Cell and Developmental Biology, 2021 Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with
Tiffany G. Roach +5 more
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The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle
Viruses, 2021 Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the
Bo Meng, Andrew M. L. Lever
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iScience, 2021 Summary: Internalized and ubiquitinated signaling receptors are silenced by their intraluminal budding into multivesicular bodies aided by the endosomal sorting complexes required for transport (ESCRT) machinery. HD-PTP, an ESCRT protein, forms complexes
Jalal M. Kazan +10 more
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