A relay race of ESCRT-III paralogs drives cell division in a hyperthermophilic archaeon [PDF]
mBioCell division is a fundamental process ensuring the perpetuation of all cellular life forms. Archaea of the order Sulfolobales divide using a simpler version of the eukaryotic endosomal sorting complexes required for transport (ESCRT) machinery, composed
Junfeng Liu +6 more
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An Inducible ESCRT-III Inhibition Tool to Control HIV-1 Budding [PDF]
Viruses, 2023 HIV-1 budding as well as many other cellular processes require the Endosomal Sorting Complex Required for Transport (ESCRT) machinery. Understanding the architecture of the native ESCRT-III complex at HIV-1 budding sites is limited due to spatial ...
Haiyan Wang +8 more
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ESCRT-III is recruited by human herpesvirus 6A nuclear egress complex to promote nuclear egress of the nucleocapsid [PDF]
Journal of VirologyHerpesviruses replicate their genomes and package them into capsids within the host cell nucleus. These capsids must then translocate from the nucleus to the cytoplasm through a process designated nuclear egress. The virus-encoded nuclear egress complex (
Aila Gulijiahani +5 more
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Accessory ESCRT‐III proteins are conserved and selective regulators of Rab11a‐exosome formation [PDF]
Journal of Extracellular Vesicles, 2023 Exosomes are secreted nanovesicles with potent signalling activity that are initially formed as intraluminal vesicles (ILVs) in late Rab7‐positive multivesicular endosomes, and also in recycling Rab11a‐positive endosomes, particularly under some forms of
Pauline P. Marie +10 more
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ESCRT-III: a versatile membrane remodeling machinery and its implications in cellular processes and diseases [PDF]
Animal Cells and SystemsThe endosomal sorting complexes required for transport (ESCRT) machinery is an evolutionarily conserved cytosolic protein complex that plays a crucial role in membrane remodeling and scission events across eukaryotes.
Jisoo Park +4 more
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The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes [PDF]
The EMBO JournalThe ESCRT machinery mediates membrane remodeling in numerous processes in cells including cell division and nuclear membrane reformation. The identification of ESCRT homologs in Asgard archaea, currently considered the closest prokaryotic relative of ...
Nataly Melnikov +10 more
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Nature Communications, 2020 ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear.
Aurélie Bertin +10 more
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Nuclear and degradative functions of the ESCRT-III pathway: implications for neurodegenerative disease [PDF]
NucleusThe ESCRT machinery plays a pivotal role in membrane-remodeling events across multiple cellular processes including nuclear envelope repair and reformation, nuclear pore complex surveillance, endolysosomal trafficking, and neuronal pruning.
Olivia Keeley, Alyssa N. Coyne
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Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery [PDF]
Cell RegenerationCells can recover from sub-lethal necrosis by repairing plasma-membrane (PM) rupture through the ESCRT-III machinery, but how this process is regulated remains unknown. Here, we identify Toll-interacting protein (Tollip) as a conserved negative regulator
Julia M. Ferrick +8 more
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Methylation of ESCRT-III components regulates the timing of cytokinetic abscission [PDF]
Nature CommunicationsAbscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB) connecting two daughter cells. Abscission requires tight control of the recruitment and polymerization of the Endosomal Protein Complex Required for Transport-III (
Aurélie Richard +15 more
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