Results 31 to 40 of about 14,736 (216)

AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.

PLoS Genetics, 2021
To complete mitosis, the bridge that links the two daughter cells needs to be cleaved. This step is carried out by the endosomal sorting complex required for transport (ESCRT) machinery. AKTIP, a protein discovered to be associated with telomeres and the
Chiara Merigliano, Romina Burla, Mattia La Torre, Simona Del Giudice, Hsiangling Teo, Chong Wai Liew, Alexandre Chojnowski, Wah Ing Goh, Yolanda Olmos, Klizia Maccaroni, Maria Giubettini, Irene Chiolo, Jeremy G Carlton, Domenico Raimondo, Fiammetta Vernì, Colin L Stewart, Daniela Rhodes, Graham D Wright, Brian E Burke, Isabella Saggio   +19 more
doaj   +1 more source

Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM

Cell Reports, 2018
Summary: The ESCRT machinery mediates membrane fission in a variety of processes in cells. According to current models, ESCRT-III proteins drive membrane fission by assembling into helical filaments on membranes.
Inna Goliand, Shai Adar-Levor, Inbar Segal, Dikla Nachmias, Tali Dadosh, Michael M. Kozlov, Natalie Elia   +6 more
doaj   +1 more source

SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. [PDF]

, 2010
Hereditary spastic paraplegias (HSPs, SPG1-46) are inherited neurological disorders characterized by lower extremity spastic weakness. Loss-of-function SPG20 gene mutations cause an autosomal recessive HSP known as Troyer syndrome.
Bakowska, Joanna C, Blackstone, Craig, Hurley, James H, Parker, Rell L, Renvoisé, Benoît, Yang, Dong   +5 more
core   +3 more sources

Novel Interactions of ESCRT-III with LIP5 and VPS4 and their Implications for ESCRT-III Disassembly [PDF]

Molecular Biology of the Cell, 2008
The AAA+ ATPase VPS4 plays an essential role in multivesicular body biogenesis and is thought to act by disassembling ESCRT-III complexes. VPS4 oligomerization and ATPase activity are promoted by binding to LIP5. LIP5 also binds to the ESCRT-III like protein CHMP5/hVps60, but how this affects its function remains unclear.
Shim, Soomin, Merrill, Samuel A, Hanson, Phyllis I   +2 more
openaire   +3 more sources

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

eLife, 2016
The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and ...
Shaogeng Tang, Nicholas J Buchkovich, W Mike Henne, Sudeep Banjade, Yun Jung Kim, Scott D Emr   +5 more
doaj   +1 more source

ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting. [PDF]

, 2012
The sorting of signaling receptors to lysosomes is an essential regulatory process in mammalian cells. During degradation, receptors are modified with ubiquitin and sorted by endosomal sorting complex required for transport (ESCRT)-0, -I, -II, and -III ...
Chen, Buxin, Dores, Michael R, Lin, Huilan, Meerloo, Timo, Montagne, William A, Paing, May M, Soh, Unice JK, Trejo, JoAnn   +7 more
core   +3 more sources

ESCRT-III/Vps4 controls heterochromatin-nuclear envelope attachments [PDF]

Developmental Cell, 2019
AbstractIn eukaryotes chromosomes are compartmentalized within the nucleus delimited by the double membrane of the nuclear envelope (NE). Defects in the function and structure of the NE are linked to disease1,2. During interphase, the NE organizes the genome and regulates its expression3.
Pieper, Gerard H., Sprenger, Simon, Teis, David, Oliferenko, Snezhana   +3 more
openaire   +5 more sources

Principles of membrane remodeling by dynamic ESCRT-III polymers [PDF]

Trends in Cell Biology, 2021
Endosomal protein complex required for transport-III (ESCRT-III) polymers are involved in many crucial cellular functions, from cell division to endosome-lysosome dynamics. As a eukaryotic membrane remodeling machinery, ESCRT-III is unique in its ability to catalyze fission of membrane necks from their luminal side and to participate in membrane ...
Pfitzner, Anna-Katharina, Moser Von Filseck, Joachim, Roux, Aurélien   +2 more
openaire   +3 more sources

Structural Basis for Autoinhibition of ESCRT-III CHMP3 [PDF]

Journal of Molecular Biology, 2008
Endosomal sorting complexes required for transport (ESCRT-0, ESCRT-I, ESCRT-II, and ESCRT-III) are selectively recruited to cellular membranes to exert their function in diverse processes, such as multivesicular body biogenesis, enveloped virus budding, and cytokinesis.
Lata, S, Roessle, M, Solomons, J, Jamin, M, Göttlinger, H.G, Svergun, D.I, Weissenhorn, W   +6 more
openaire   +4 more sources

Membrane Remodeling: ESCRT-III Filaments as Molecular Garrotes [PDF]

Current Biology, 2020
New reconstitution, biochemical and structural studies are revealing how the core machinery of the ESCRT pathway constricts membranes to promote fission. Equally exciting is the discovery and characterization of conserved ESCRT-like machinery across all three domains of life.
John, McCullough, Wesley I, Sundquist
openaire   +2 more sources