Results 31 to 40 of about 10,382 (181)

Vps68 cooperates with ESCRT-III in intraluminal vesicle formation [PDF]

Journal of Cell Science, 2022
Abstract The endosomal sorting complex required for transport (ESCRT)-III mediates budding and abscission of intraluminal vesicles (ILVs) into multivesicular endosomes. To further define the role of the ESCRT-III associated protein Mos10/Vps60 in ILV formation, we screened for new interaction partners by SILAC/MS ...
Sören Alsleben, Ralf Kölling
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The role of VPS4 in ESCRT-III polymer remodeling [PDF]

Biochemical Society Transactions, 2019
Abstract The endosomal sorting complex required for transport-III (ESCRT-III) and VPS4 catalyze a variety of membrane-remodeling processes in eukaryotes and archaea. Common to these processes is the dynamic recruitment of ESCRT-III proteins from the cytosol to the inner face of a membrane neck structure, their activation and filament ...
Caillat, Christophe, Maity, Sourav, Miguet, Nolwenn, Roos, Wouter, Weissenhorn, Winfried   +4 more
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Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM

Cell Reports, 2018
Summary: The ESCRT machinery mediates membrane fission in a variety of processes in cells. According to current models, ESCRT-III proteins drive membrane fission by assembling into helical filaments on membranes.
Inna Goliand, Shai Adar-Levor, Inbar Segal, Dikla Nachmias, Tali Dadosh, Michael M. Kozlov, Natalie Elia   +6 more
doaj   +1 more source

Regulation of Vps4 ATPase activity by ESCRT-III [PDF]

Biochemical Society Transactions, 2009
MVB (multivesicular body) formation occurs when the limiting membrane of an endosome invaginates into the intraluminal space and buds into the lumen, bringing with it a subset of transmembrane cargoes. Exvagination of the endosomal membrane from the cytosol is topologically similar to the budding of retroviral particles and cytokinesis, wherein ...
Brian A, Davies, Ishara F, Azmi, David J, Katzmann   +2 more
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ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

eLife, 2016
The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and ...
Shaogeng Tang, Nicholas J Buchkovich, W Mike Henne, Sudeep Banjade, Yun Jung Kim, Scott D Emr   +5 more
doaj   +1 more source

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

eLife, 2014
The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this ...
Anil G Cashikar, Soomin Shim, Robyn Roth, Michael R Maldazys, John E Heuser, Phyllis I Hanson   +5 more
doaj   +1 more source

CDK1 controls CHMP7-dependent nuclear envelope reformation

eLife, 2021
Through membrane sealing and disassembly of spindle microtubules, the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) machinery has emerged as a key player in the regeneration of a sealed nuclear envelope (NE) during mitotic exit, and in
Alberto T Gatta, Yolanda Olmos, Caroline L Stoten, Qu Chen, Peter B Rosenthal, Jeremy G Carlton   +5 more
doaj   +1 more source

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection.

PLoS Pathogens, 2022
As the important molecular machinery for membrane protein sorting in eukaryotic cells, the endosomal sorting and transport complexes (ESCRT-0/I/II/III and VPS4) usually participate in various replication stages of enveloped viruses, such as endocytosis ...
Chun-Chun Liu, Ya-Yun Liu, Jiang-Fei Zhou, Xi Chen, Huan Chen, Jia-Huan Hu, Jing Chen, Jin Zhang, Rui-Cong Sun, Jian-Chao Wei, Yun Young Go, Eiji Morita, Bin Zhou   +12 more
doaj   +1 more source

Assembly of the AAA ATPase Vps4 on ESCRT-III [PDF]

Molecular Biology of the Cell, 2010
Vps4 is a key enzyme that functions in endosomal protein trafficking, cytokinesis, and retroviral budding. Vps4 activity is regulated by its recruitment from the cytoplasm to ESCRT-III, where the protein oligomerizes into an active ATPase. The recruitment and oligomerization steps are mediated by a complex network of at least 12 distinct interactions ...
Shestakova, Anna, Hanono, Abraham, Drosner, Stacey, Curtiss, Matt, Davies, Brian A., Katzmann, David J., Babst, Markus   +6 more
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Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum

Frontiers in Microbiology, 2019
Multivesicular bodies (MVBs) are critical intermediates in the trafficking of ubiquitinated endocytosed surface proteins to the lysosome/vacuole for destruction.
Qiurong Xie, Qiurong Xie, Ahai Chen, Ahai Chen, Yunzhi Zhang, Yunzhi Zhang, Mingyue Yuan, Mingyue Yuan, Wei Xie, Wei Xie, Chengkang Zhang, Chengkang Zhang, Wenhui Zheng, Wenhui Zheng, Zonghua Wang, Zonghua Wang, Guangpu Li, Guangpu Li, Jie Zhou, Jie Zhou   +19 more
doaj   +1 more source