Results 41 to 50 of about 10,382 (181)
Femtoliter Injection of ESCRT-III Proteins into Adhered Giant Unilamellar Vesicles
Bio-Protocol, 2022 The endosomal sorting complex required for transport (ESCRT) machinery mediates membrane fission reactions that exhibit a different topology from that observed in clathrin-coated vesicles.
Vasil Georgiev +3 more
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Journal of Cell Biology, 2011 ![Figure][1] More intralumenal vesicles (red) break away from the endosome membrane in control cells (left) than in cells that overexpress a domain of Bro1 (right). The protein Bro1 lives up to its name, [Wemmer et al.][2] show.
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Membrane Constriction and Thinning by Sequential ESCRT-III Polymerization [PDF]
Biophysical Journal, 2019 Abstract The Endosomal Sorting Complexes Required for Transport (ESCRTs) mediate diverse membrane remodeling events. These activities typically require ESCRT-III proteins to stabilize negatively-curved membranes, although recent work has indicated that certain ESCRT-IIIs also participate in positive-curvature membrane shaping reactions.
Nguyen, Henry C. +8 more
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eLife, 2017 The ESCRT machinery mediates reverse membrane scission. By quantitative fluorescence lattice light-sheet microscopy, we have shown that ESCRT-III subunits polymerize rapidly on yeast endosomes, together with the recruitment of at least two Vps4 hexamers.
Manuel Alonso Y Adell +15 more
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ESCRT-III gets the bends [PDF]
Journal of Cell Biology, 2014 ![Figure][1] The Vps32 subunits in the ESCRT-III complex naturally assemble into spirals. Shen et al. reveal how a key portion of the membrane-snipping ESCRT-III complex gets in shape.
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ESCRT-III–dependent membrane repair blocks ferroptosis [PDF]
Biochemical and Biophysical Research Communications, 2020 Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid peroxidation. Although plasma membrane injuries represent an important event in cell death, the impact of membrane repair mechanisms on ferroptosis remains unidentified.
Enyong Dai +4 more
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ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
PLoS ONE, 2014 Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon +4 more
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Frontiers in Cellular and Infection Microbiology, 2021 The endosomal sorting complex required for transport (ESCRT) is formed by ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III complexes, and accessory proteins. It conducts vesicular trafficking in eukaryotes through the formation of vesicles and membrane fission and ...
Ausencio Galindo +8 more
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Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico
BMC Biology, 2019 Background ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane ...
Lena Harker-Kirschneck +2 more
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ESCRT-III mediated cell division in Sulfolobus acidocaldarius –A reconstitution perspective
Frontiers in Microbiology, 2014 In the framework of Synthetic Biology, it has become an intriguing question what would be the minimal representation of cell division machinery. Thus, it seems appropriate to compare how cell division is realized in different microorganisms.
Tobias eHärtel, Petra eSchwille
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