Results 1 to 10 of about 19,636 (235)

ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis

eLife, 2016
The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and ...
Shaogeng Tang, Nicholas J Buchkovich, W Mike Henne, Sudeep Banjade, Yun Jung Kim, Scott D Emr   +5 more
doaj   +3 more sources

The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair [PDF]

The EMBO Journal
After damage from pathogenic, chemical or physical stress, endolysosomal membranes are repaired and resealed by the endosomal sorting complex required for transport (ESCRT) machinery, but how this membrane damage is sensed and translated into ESCRT ...
Dale P Corkery, Deerada Wijayatunga, Benedita K L Feron, Laura K Herzog, Anastasia Knyazeva, Yao-Wen Wu   +5 more
doaj   +2 more sources

Insights into the function of ESCRT and its role in enveloped virus infection

Frontiers in Microbiology, 2023
The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang, Yu Chen, Shunlin Hu, Xiufan Liu, Xiufan Liu, Xiufan Liu   +5 more
doaj   +1 more source

The endosomal sorting complex required for transport repairs the membrane to delay cell death

Frontiers in Oncology, 2022
The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang, Min Wang, Ying-Ying Zhang, Shu-Zhi Zhao, Shu-Zhi Zhao, Song Gu   +5 more
doaj   +1 more source

Design principles of the ESCRT-III Vps24-Vps2 module

eLife, 2021
ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative contributions of the eight ESCRT-III subunits differ between each process.
Sudeep Banjade, Yousuf H Shah, Shaogeng Tang, Scott D Emr   +3 more
doaj   +1 more source

ESCRT-III function in membrane fission and repair [PDF]

Nature Reviews Molecular Cell Biology
Jeremy Carlton, Matteo Burigotto
exaly   +2 more sources

Component Interaction of ESCRT Complexes Is Essential for Endocytosis-Dependent Growth, Reproduction, DON Production and Full Virulence in Fusarium graminearum

Frontiers in Microbiology, 2019
Multivesicular bodies (MVBs) are critical intermediates in the trafficking of ubiquitinated endocytosed surface proteins to the lysosome/vacuole for destruction.
Qiurong Xie, Qiurong Xie, Ahai Chen, Ahai Chen, Yunzhi Zhang, Yunzhi Zhang, Mingyue Yuan, Mingyue Yuan, Wei Xie, Wei Xie, Chengkang Zhang, Chengkang Zhang, Wenhui Zheng, Wenhui Zheng, Zonghua Wang, Zonghua Wang, Guangpu Li, Guangpu Li, Jie Zhou, Jie Zhou   +19 more
doaj   +1 more source

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection.

PLoS Pathogens, 2022
As the important molecular machinery for membrane protein sorting in eukaryotic cells, the endosomal sorting and transport complexes (ESCRT-0/I/II/III and VPS4) usually participate in various replication stages of enveloped viruses, such as endocytosis ...
Chun-Chun Liu, Ya-Yun Liu, Jiang-Fei Zhou, Xi Chen, Huan Chen, Jia-Huan Hu, Jing Chen, Jin Zhang, Rui-Cong Sun, Jian-Chao Wei, Yun Young Go, Eiji Morita, Bin Zhou   +12 more
doaj   +1 more source

ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis [PDF]

Open Biology, 2016
Endocytosis and local protein synthesis (LPS) act coordinately to mediate the chemotropic responses of axons, but the link between these two processes is poorly understood.
Filip A. Konopacki, Hovy Ho-Wai Wong, Asha Dwivedy, Anaïs Bellon, Michael D. Blower, Christine E. Holt   +5 more
doaj   +1 more source

Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration

Autophagy Reports, 2023
Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death.
Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L. Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S. Weisman   +16 more
doaj   +1 more source