Structure of cellular ESCRT-III spirals and their relationship to HIV budding [PDF]
eLife, 2014 The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this ...
Anil G Cashikar +5 more
doaj +5 more sources
The ATG8 E3-like ligases sense lysosomal damage and initiate ESCRT-mediated membrane repair [PDF]
The EMBO JournalAfter damage from pathogenic, chemical or physical stress, endolysosomal membranes are repaired and resealed by the endosomal sorting complex required for transport (ESCRT) machinery, but how this membrane damage is sensed and translated into ESCRT ...
Dale P Corkery +5 more
doaj +2 more sources
The Dynamics of the ESCRT Machinery in Open Mitosis from Physiology to Pathology [PDF]
CellsThe Endosomal Sorting Complex Required for Transport (ESCRT) is a highly conserved machinery best known for its role in endosomal trafficking and membrane remodeling.
Mattia La Torre +3 more
doaj +2 more sources
ESCRT-III function in membrane fission and repair [PDF]
Nature Reviews Molecular Cell BiologyMatteo Burigotto, Jeremy G Carlton
exaly +2 more sources
Insights into the function of ESCRT and its role in enveloped virus infection
Frontiers in Microbiology, 2023 The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang +5 more
doaj +1 more source
A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe [PDF]
, 2014 Cytokinesis and cell separation are critical events in the cell cycle. We show that Endosomal Sorting Complex Required for Transport (ESCRT) genes are required for cell separation in Schizosaccharomyces pombe.
Bhutta, Musab S. +3 more
core +17 more sources
The endosomal sorting complex required for transport repairs the membrane to delay cell death
Frontiers in Oncology, 2022 The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang +5 more
doaj +1 more source
Design principles of the ESCRT-III Vps24-Vps2 module
eLife, 2021 ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative contributions of the eight ESCRT-III subunits differ between each process.
Sudeep Banjade +3 more
doaj +1 more source
Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response [PDF]
, 2018 Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms.
Hanson, Phyllis I +7 more
core +2 more sources
PLoS Pathogens, 2022 As the important molecular machinery for membrane protein sorting in eukaryotic cells, the endosomal sorting and transport complexes (ESCRT-0/I/II/III and VPS4) usually participate in various replication stages of enveloped viruses, such as endocytosis ...
Chun-Chun Liu +12 more
doaj +1 more source