Results 31 to 40 of about 28,813 (238)
MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. [PDF]
PLoS ONE, 2007 After ligand binding and endocytosis, cell surface receptors can continue to signal from endosomal compartments until sequestered from the cytoplasm. An important mechanism for receptor downregulation in vivo is via the inward budding of receptors into ...
Anjon Audhya +3 more
doaj +1 more source
WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]
, 2015 Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T +6 more
core +1 more source
Multidimensional Analysis of CHMP Family Members in Hepatocellular Carcinoma
International Journal of General Medicine, 2022 Yu Guo,1 An Shang,1 Shuang Wang,2 Min Wang1 1Department of General Surgery, Jilin University Second Hospital, Changchun, Jilin, People’s Republic of China; 2Department of Dermatology, Jilin University Second Hospital, Changchun, Jilin, People’s Republic ...
Guo Y, Shang A, Wang S, Wang M
doaj
Resolving ESCRT-III Spirals at the Intercellular Bridge of Dividing Cells Using 3D STORM
Cell Reports, 2018 Summary: The ESCRT machinery mediates membrane fission in a variety of processes in cells. According to current models, ESCRT-III proteins drive membrane fission by assembling into helical filaments on membranes.
Inna Goliand +6 more
doaj +1 more source
ESCRT machinery plays a role in microautophagy in yeast
BMC Molecular and Cell Biology, 2020 Background Microautophagy, which degrades cargos by direct lysosomal/vacuolar engulfment of cytoplasmic cargos, is promoted after nutrient starvation and the inactivation of target of rapamycin complex 1 (TORC1) protein kinase.
Shamsul Morshed +2 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 The endosomal sorting complex required for transport (ESCRT) is formed by ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III complexes, and accessory proteins. It conducts vesicular trafficking in eukaryotes through the formation of vesicles and membrane fission and ...
Ausencio Galindo +8 more
doaj +1 more source
The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. [PDF]
, 2015 The sorting of G protein-coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR ...
Dores, Michael R +4 more
core +1 more source
Autophagy Reports, 2023 Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death.
Ron Benyair +16 more
doaj +1 more source
ESCRT Requirements for Murine Leukemia Virus Release
Viruses, 2016 The Murine Leukemia Virus (MLV) is a gammaretrovirus that hijack host components of the endosomal sorting complex required for transport (ESCRT) for budding.
Christina Bartusch, Reinhild Prange
doaj +1 more source
Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes. [PDF]
, 2020 The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I. +6 more
core +1 more source