Results 21 to 30 of about 19,636 (235)
ESCRTing Membrane Deformation [PDF]
Cell, 2009 The ESCRT-III complex mediates membrane budding away from the cytosol in endosome biogenesis, cytokinesis, and viral budding. In this issue, Saksena et al. (2009) use an elegant fluorescence-based approach to define the sequential activation, recruitment, and disassembly of ESCRT-III subunits during membrane involution in vitro.
Malerød, Lene, Stenmark, Harald
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Cell, 2017 Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
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Biology of the Cell, 2010 Components of the ESCRT (endosomal sorting complex required for transport) machinery mediate endosomal sorting of ubiquitinated membrane proteins. They are key regulators of biological processes important for cell growth and survival, such as growth‐factor‐mediated signalling and cytokinesis.
Ingrid, Roxrud +2 more
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
The ESCRTs – converging on mechanism [PDF]
Journal of Cell Science, 2020 ABSTRACT The endosomal sorting complexes required for transport (ESCRTs) I, -II and –III, and their associated factors are a collection of ∼20 proteins in yeast and ∼30 in mammals, responsible for severing membrane necks in processes that range from multivesicular body formation, HIV release and cytokinesis, to plasma and lysosomal ...
Mark Remec Pavlin, James H. Hurley
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ESCRT-mediated phagophore sealing during mitophagy [PDF]
, 2019 Inactivation of the endosomal sorting complex required for transport (ESCRT) machinery has been reported to cause autophagic defects, but the exact functions of ESCRT proteins in macroautophagy/autophagy remain incompletely understood.
Andreas Brech (214227) +12 more
core +1 more source
Science, 2008 Two pathways within endosomes use specific protein complexes or membrane domains to direct cargo for degradation or secretion from cells.
Marsh, M., van Meer, G.
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The ESCRT machinery at a glance [PDF]
Journal of Cell Science, 2009 This article is part of a Minifocus on the ESCRT machinery. For further reading, please see related articles: `No strings attached: the ESCRT machinery in viral budding and cytokinesis' by Bethan McDonald and Juan Martin-Serrano (J. Cell Sci.
Thomas, Wollert +5 more
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The EMBO Journal, 2015 The ESCRT proteins are an ancient system that buds membranes and severs membrane necks from their inner face. Three "classical" functions of the ESCRTs have dominated research into these proteins since their discovery in 2001: the biogenesis of multivesicular bodies in endolysosomal sorting; the budding of HIV-1 and other viruses from the plasma ...
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The host ESCRT machinery and nonviral pathogens. [PDF]
, 2023 The outcome of intracellular bacterial infection is affected by the host ESCRT machinery. (1) Brucella abortus recruits ESCRT components to its PVC, which resembles an MVB, to promote proliferation and release. (2) Salmonella spp.
Vern B. Carruthers (8462907) +1 more
core +1 more source