Results 11 to 20 of about 28,813 (238)
ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis
eLife, 2016 The endosomal sorting complexes required for transport (ESCRT) pathway facilitates multiple fundamental membrane remodeling events. Previously, we determined X-ray crystal structures of ESCRT-III subunit Snf7, the yeast CHMP4 ortholog, in its active and ...
Shaogeng Tang +5 more
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Cell, 2017 Necroptosis is a highly inflammatory form of programmed cell death that results from MLKL-mediated disruption of the cell membrane. In this issue of Cell, Gong et al. challenge the notion that MLKL activation is a point of no return by identifying mechanisms to counterbalance necroptosis, sustain plasma membrane integrity, and prolong cell viability.
Hongyan, Guo, William J, Kaiser
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Biology of the Cell, 2010 Components of the ESCRT (endosomal sorting complex required for transport) machinery mediate endosomal sorting of ubiquitinated membrane proteins. They are key regulators of biological processes important for cell growth and survival, such as growth‐factor‐mediated signalling and cytokinesis.
Ingrid, Roxrud +2 more
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Current Biology, 2012 The endosomal sorting complexes required for transport (ESCRT) assemble into a multisubunit machinery that performs a topologically unique membrane bending and scission reaction away from the cytoplasm. This evolutionarily highly conserved process is required for the multivesicular body (MVB) pathway, cytokinesis and HIV budding.
Schmidt, Oliver, Teis, David
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Developmental Cell, 2011 Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission.
Henne, William M. +2 more
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The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication. [PDF]
FASEB JAlix and VPS4A function in HBV biogenesis and degradation in the context of the endosomal and autophagic pathways. Alix and VPS4A orchestrate HBV secretion and degradation via endosomal and autophagic pathways. Under normal conditions, ESCRT ensures efficient virion budding and MVB formation.
Li J +5 more
europepmc +2 more sources
ESCRTing Membrane Deformation [PDF]
Cell, 2009 The ESCRT-III complex mediates membrane budding away from the cytosol in endosome biogenesis, cytokinesis, and viral budding. In this issue, Saksena et al. (2009) use an elegant fluorescence-based approach to define the sequential activation, recruitment, and disassembly of ESCRT-III subunits during membrane involution in vitro.
Malerød, Lene, Stenmark, Harald
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Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function inDrosophilaby efficient isolation of ESCRT mutants [PDF]
Journal of Cell Science, 2009 ESCRT proteins were initially isolated in yeast as a single functional set of conserved components controlling endosomal cargo sorting and multivesicular body (MVB) biogenesis. Recent work has suggested that metazoan ESCRT proteins might have more functionally diverse roles, but the limited availability of ESCRT mutants in species other than yeast has ...
T. Vaccari +6 more
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ESCRT-III mediated cell division in Sulfolobus acidocaldarius - a reconstitution perspective [PDF]
, 2014 In the framework of synthetic biology, it has become an intriguing question what would be the minimal representation of cell division machinery. Thus, it seems appropriate to compare how cell division is realized in different microorganisms. Inparticular,
Härtel, T., Schwille, P.
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Developmental Cell, 2002 interaction with Ub- cargo, PI3P, ESCRT-I (Vps23)Ub-cargo interaction, Interaction with Rsp5Ub-cargo and ESCRT-0 (Vps27) interactioninteraction with ESCRT-II (Vps36)interaction with PI3P, Ub-cargo, ESCRT-I (Vps28)interaction with ESCRT-III (Vps20)nucleator for Snf7 oligomerizationhomo- oligomer, cargo sequestration, membrane deformationcap for Snf7 ...
Babst, Markus +4 more
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