Results 21 to 30 of about 14,736 (216)
Physical mechanisms of ESCRT-III-driven cell division. [PDF]
Proc Natl Acad Sci U S A, 2022 Significance Cell division is an essential requirement for life. Division requires mechanical forces, often exerted by protein assemblies from the cell interior, that split a single cell into two. Using coarse-grained computer simulations and live cell imaging we define a distinct cell division mechanism—based on the forces ...
Harker-Kirschneck L +11 more
europepmc +5 more sources
The endosomal sorting complex required for transport repairs the membrane to delay cell death
Frontiers in Oncology, 2022 The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang +5 more
doaj +1 more source
A complex network of interactions between mitotic kinases, phosphatases and ESCRT proteins regulates septation and membrane trafficking in S. pombe [PDF]
, 2014 Cytokinesis and cell separation are critical events in the cell cycle. We show that Endosomal Sorting Complex Required for Transport (ESCRT) genes are required for cell separation in Schizosaccharomyces pombe.
Bhutta, Musab S. +3 more
core +16 more sources
Insights into the function of ESCRT and its role in enveloped virus infection
Frontiers in Microbiology, 2023 The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang +5 more
doaj +1 more source
eLife, 2022 The 12 related human ESCRT-III proteins form filaments that constrict membranes and mediate fission, including during cytokinetic abscission. The C-terminal tails of polymerized ESCRT-III subunits also bind proteins that contain Microtubule-Interacting ...
Dawn M Wenzel +6 more
doaj +1 more source
ESCRT-III–dependent membrane repair blocks ferroptosis [PDF]
Biochemical and Biophysical Research Communications, 2020 Ferroptosis is a form of regulated cell death that is triggered by iron accumulation and lipid peroxidation. Although plasma membrane injuries represent an important event in cell death, the impact of membrane repair mechanisms on ferroptosis remains unidentified.
Enyong Dai +4 more
openaire +2 more sources
Bro1 binds the Vps20 subunit of ESCRT-III and promotes ESCRT-III regulation by Doa4. [PDF]
Traffic, 2022 AbstractThe budding of intralumenal vesicles (ILVs) at endosomes requires membrane scission by the ESCRT‐III complex. This step is negatively regulated in yeast by Doa4, the ubiquitin hydrolase that deubiquitinates transmembrane proteins sorted as cargoes into ILVs. Doa4 acts non‐enzymatically to inhibit ESCRT‐III membrane scission activity by directly
Buysse D, West M, Leih M, Odorizzi G.
europepmc +3 more sources
Structural basis for ESCRT-III protein autoinhibition [PDF]
Nature Structural & Molecular Biology, 2009 Endosomal sorting complexes required for transport-III (ESCRT-III) subunits cycle between two states: soluble monomers and higher-order assemblies that bind and remodel membranes during endosomal vesicle formation, midbody abscission and enveloped virus budding.
Bajorek, Monika +9 more
openaire +2 more sources
Annexin A7 mediates lysosome repair independently of ESCRT-III. [PDF]
Front Cell Dev Biol, 2023 Lysosomes are crucial organelles essential for various cellular processes, and any damage to them can severely compromise cell viability. This study uncovers a previously unrecognized function of the calcium- and phospholipid-binding protein Annexin A7 in lysosome repair, which operates independently of the Endosomal Sorting Complex Required for ...
Ebstrup ML +8 more
europepmc +7 more sources
The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes
Membranes, 2022 The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,
Yolanda Olmos
doaj +1 more source