Results 11 to 20 of about 10,382 (181)
ESCRT-III function in membrane fission and repair [PDF]
Nature Reviews Molecular Cell BiologyThe endosomal sorting complex required for transport (ESCRT) machinery is an evolutionarily conserved multisubunit protein complex that remodels cellular membranes. Beyond its classical role in endosomal sorting, the ESCRT machinery has been implicated in an ever-growing number of functions, including viral budding, cytokinesis, autophagy ...
Jeremy Carlton, Matteo Burigotto
exaly +5 more sources
Design principles of the ESCRT-III Vps24-Vps2 module [PDF]
eLife, 2021 ESCRT-III polymerization is required for all endosomal sorting complex required for transport (ESCRT)-dependent events in the cell. However, the relative contributions of the eight ESCRT-III subunits differ between each process.
Sudeep Banjade +3 more
doaj +3 more sources
Modelling membrane reshaping by staged polymerization of ESCRT-III filaments. [PDF]
PLoS Computational Biology, 2022 ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III filaments undergo a series of dramatic composition and geometry changes in the presence of an
Xiuyun Jiang +7 more
doaj +2 more sources
VPS4B orchestrates response to nuclear envelope stress by regulating ESCRT-III dynamics in glioblastoma [PDF]
NucleusThe Nuclear envelope (NE) is frequently challenged by mechanical stimuli involving cells passing through a tight space and such stress is known as “NE stress.” Various factors that cooperate to repair the NE have been identified, including endosomal ...
Zuqian Wu +4 more
doaj +2 more sources
ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity
Nature Communications, 2018 The endosomal sorting complex required for transport-III (ESCRT-III) has been implicated in the packaging of HIV and HSV-1 viruses in the cytoplasm. Here the authors show that ESCRT-III proteins are required for the transport of HSV-1 nucleocapsids from ...
Jun Arii +9 more
doaj +2 more sources
Vps60 initiates alternative ESCRT-III filaments. [PDF]
J Cell Biol, 2023 Endosomal sorting complex required for transport-III (ESCRT-III) participates in essential cellular functions, from cell division to endosome maturation. The remarkable increase of its subunit diversity through evolution may have enabled the acquisition of novel functions. Here, we characterize a novel ESCRT-III copolymer initiated by Vps60.
Pfitzner AK +7 more
europepmc +4 more sources
Developmental Cell, 2002 The endosomal sorting complex required for transport (ESCRT) system is essential for multivesicular body biogenesis, in which cargo sorting is coupled to the invagination and scission of intralumenal vesicles. The ESCRTs are also needed for budding of enveloped viruses including human immunodeficiency virus 1, and for membrane abscission in cytokinesis.
Babst, Markus +4 more
openaire +4 more sources
The endosomal sorting complex required for transport repairs the membrane to delay cell death
Frontiers in Oncology, 2022 The endosomal sorting complex required for transport (ESCRT) machinery plays a key role in the repair of damaged plasma membranes with puncta form and removes pores from the plasma membrane in regulated cell death, apoptosis, necroptosis, pyroptosis ...
Ye Yang +5 more
doaj +1 more source
Bro1 binds the Vps20 subunit of ESCRT-III and promotes ESCRT-III regulation by Doa4. [PDF]
Traffic, 2022 AbstractThe budding of intralumenal vesicles (ILVs) at endosomes requires membrane scission by the ESCRT‐III complex. This step is negatively regulated in yeast by Doa4, the ubiquitin hydrolase that deubiquitinates transmembrane proteins sorted as cargoes into ILVs. Doa4 acts non‐enzymatically to inhibit ESCRT‐III membrane scission activity by directly
Buysse D, West M, Leih M, Odorizzi G.
europepmc +3 more sources
Insights into the function of ESCRT and its role in enveloped virus infection
Frontiers in Microbiology, 2023 The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang +5 more
doaj +1 more source