Results 1 to 10 of about 12,869 (202)
Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10 [PDF]
Nature Communications, 2021 Salmonella secretes the effector protein SopD into the host cell cytoplasm, leading to scission of the plasma membrane through unclear mechanisms. Here, Boddy et al.
Kirsten C. Boddy +11 more
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Annual Review of Cell and Developmental Biology, 2013 Virus budding is a complex, multistep process in which viral proteins make specific alterations in membrane curvature. Many different viral proteins can deform the membrane and form a budding virion, but very few can mediate membrane scission to complete the budding process.
Jeremy S Rossman, Robert Lamb
exaly +7 more sources
Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission [PDF]
Scientific Reports, 2017 AbstractMembrane scission is a crucial step in all budding processes, from endocytosis to viral budding. Many proteins have been associated with scission, though the underlying molecular details of how scission is accomplished often remain unknown. Here, we investigate the process of M2-mediated membrane scission during the budding of influenza viruses.
Jeremy S Rossman +2 more
exaly +8 more sources
Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly [PDF]
eLife, 2018 The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson +2 more
doaj +4 more sources
Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1 [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 The endosomal sorting complexes required for transport (ESCRT) system is an ancient and ubiquitous membrane scission machinery that catalyzes the budding and scission of membranes.
James Hurley +2 more
exaly +5 more sources
Autophagosome closure requires membrane scission [PDF]
Autophagy, 2015 During the intracellular process of macroautophagy (hereafter autophagy), a membrane-bound organelle, the autophagosome, is generated de novo. The remodeling of the autophagic membrane during the life cycle of the organelle is a complex multistep process and involves several changes in the topology of the autophagic membrane.
Reinhard Lipowsky +2 more
exaly +7 more sources
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]
TrafficHuman EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D +3 more
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The ESCRT Machinery: Remodeling, Repairing, and Sealing Membranes
Membranes, 2022 The ESCRT machinery is an evolutionarily conserved membrane remodeling complex that is used by the cell to perform reverse membrane scission in essential processes like protein degradation, cell division, and release of enveloped retroviruses. ESCRT-III,
Yolanda Olmos
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Domes and cones: Adhesion-induced fission of membranes by ESCRT proteins. [PDF]
PLoS Computational Biology, 2018 ESCRT proteins participate in the fission step of exocytic membrane budding, by assisting in the closure and scission of the membrane neck that connects the nascent bud to the plasma membrane.
Jaime Agudo-Canalejo, Reinhard Lipowsky
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Modelling membrane reshaping by staged polymerization of ESCRT-III filaments.
PLoS Computational Biology, 2022 ESCRT-III filaments are composite cytoskeletal polymers that can constrict and cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III filaments undergo a series of dramatic composition and geometry changes in the presence of an
Xiuyun Jiang +7 more
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