The proper assembly and dissemination of progeny virions is a fundamental step in virus replication. As a whole, viruses have evolved a myriad of strategies to exploit cellular compartments and mechanisms to ensure a successful round of infection.
Kevin M. Rose +3 more
doaj +1 more source
Shear-Driven Instabilities of Membrane Tubes and Dynamin-Induced Scission [PDF]
Main Text: 5 pages, 3 figures + S.I. 14 pages, 6 figures (Accepted Version)
Sami C. Al-Izzi +2 more
openaire +4 more sources
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. [PDF]
Significance Mitochondrial fission is critical for mammalian cell division, mitophagy, and development. Fission initiates via recruitment of dynamin-related GTPases to the mitochondrial surface. In yeast and human, the recruitment utilizes adaptors that differ in sequence and predicted structure.
Koirala S +6 more
europepmc +4 more sources
ESCRT membrane scission revealed by optical tweezers. [PDF]
ESCRT proteins catalyze the function of membrane budding and scission from the inside of the cytosol to the outside. This process is fundamental in cell biology, comprising multivesicular endosome biogenesis, cytokinesis, viral budding (e.g. HIV, Ebola, Dengue) and other pathways.
Johannes Schöneberg +10 more
openaire +1 more source
Fusion and scission of membranes: Ubiquitous topological transformations in cells [PDF]
The 2016 Nobel Prizes were awarded to Yoshinori Ohsumi for autophagy and to David Thouless, Duncan Haldane and Michael Kosterlitz for topological transitions. Both of these phenomena are intrinsically related when it comes to membranes. Here, we give a brief account on topological transformations of lipid membranes, commonly known as membrane fusion ...
Knorr, R., Mizushima, N., Dimova, R.
openaire +4 more sources
Endosomal recycling tubule scission and integrin recycling involve the membrane curvature supporting protein LITAF [PDF]
Recycling to the cell surface requires the scission of tubular membrane intermediates emanating from endosomes. Here we identify the monotopicmembrane protein LITAF (LPS-Induced TNF Activating Factor) and the related CDIP1 (Cell Death Involved p53 target
Yarwood, Rebecca +5 more
core +1 more source
Insights into the function of ESCRT and its role in enveloped virus infection
The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular bodies (MVBs).
Chunxuan Wang +5 more
doaj +1 more source
Alterations of membrane curvature during influenza virus budding [PDF]
Influenza A virus belongs to the Orthomyxoviridae family. It is an enveloped virus that contains a segmented and negative-sense RNA genome. Influenza A viruses cause annual epidemics and occasional major pandemics, are a major cause of morbidity and ...
Martyna, Agnieszka, Rossman, Jeremy S.
core +1 more source
A feedback loop between dynamin and actin recruitment during clathrin-mediated endocytosis.
Clathrin-mediated endocytosis proceeds by a sequential series of reactions catalyzed by discrete sets of protein machinery. The final reaction in clathrin-mediated endocytosis is membrane scission, which is mediated by the large guanosine triophosphate ...
Marcus J Taylor +2 more
doaj +1 more source
Crucial Role for Membrane Fluidity in Proliferation of Primitive Cells
The cell wall is a defining structural feature of the bacterial subkingdom. However, most bacteria are capable of mutating into a cell-wall-deficient “L-form” state, requiring remarkable physiological and structural adaptations. L-forms proliferate by an
Romain Mercier +2 more
doaj +1 more source

