Results 11 to 20 of about 12,869 (202)
Regulation of membrane scission in yeast endocytosis. [PDF]
Mol Biol Cell, 2022 Yeast N-BAR protein complex Rvs regulates scission of clathrin-coated endocytic vesicles. Rvs is recruited by its curvature-sensing BAR domain as well as curvature independently by its SH3 domain. Rvs allows invagination growth by scaffolding the membrane and thereby delaying scission. Rvs also regulates the dynamics of the endocytic actin network.
Menon D, Hummel D, Kaksonen M.
europepmc +6 more sources
Membrane scission driven by the PROPPIN Atg18. [PDF]
EMBO J, 2017 Sorting, transport, and autophagic degradation of proteins in endosomes and lysosomes, as well as the division of these organelles, depend on scission of membrane-bound tubulo-vesicular carriers. How scission occurs is poorly understood, but family proteins bind these membranes.
Gopaldass N +4 more
europepmc +9 more sources
Reverse-topology membrane scission by the ESCRT proteins. [PDF]
Nat Rev Mol Cell Biol, 2017 The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles ...
Schöneberg J +3 more
europepmc +10 more sources
Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis. [PDF]
Nature, 2015 During endocytosis, energy is invested to narrow the necks of cargo-containing plasma membrane invaginations to radii at which the opposing segments spontaneously coalesce, thereby leading to the detachment by scission of endocytic uptake carriers. In the clathrin pathway, dynamin uses mechanical energy from GTP hydrolysis to this effect, assisted by ...
Renard HF +14 more
europepmc +9 more sources
ATP-dependent force generation and membrane scission by ESCRT-III and Vps4. [PDF]
Science, 2018 Abstract The ESCRTs catalyze reverse-topology scission from the inner face of membrane necks in HIV budding, multivesicular endosome biogenesis, cytokinesis, and other pathways. We encapsulated a minimal ESCRT module consisting of ESCRT-III subunits Snf7, Vps24, and Vps2, and the AAA +
Schöneberg J +11 more
europepmc +14 more sources
Membrane scission by the ESCRT-III complex [PDF]
Nature, 2009 The endosomal sorting complex required for transport (ESCRT) system is essential for multivesicular body biogenesis, in which cargo sorting is coupled to the invagination and scission of intralumenal vesicles. The ESCRTs are also needed for budding of enveloped viruses including human immunodeficiency virus 1, and for membrane abscission in cytokinesis.
James Hurley +2 more
exaly +5 more sources
Determinants of endocytic membrane geometry, stability, and scission [PDF]
Proceedings of the National Academy of Sciences, 2011 During endocytic vesicle formation, distinct subdomains along the membrane invagination are specified by different proteins, which bend the membrane and drive scission. Bin-Amphiphysin-Rvs (BAR) and Fer-CIP4 homology-BAR (F-BAR) proteins can induce membrane curvature and have been suggested to facilitate membrane invagination and scission.
Takuma, Kishimoto +5 more
openaire +4 more sources
Regulation of membrane scission in yeast endocytosis [PDF]
, 2018 Endocytosis is an ancient pathway that regulates communication of the cell with its environment. During this process, the plasma membrane is reshaped in a controlled sequence: a flat membrane forms an invagination that undergoes scission to produce a cargo-filled vesicle. Breaking the membrane invagination to form a vesicle is perhaps the most dramatic
Menon, Deepikaa
openaire +2 more sources
Assembly and disassembly of the ESCRT-III membrane scission complex. [PDF]
FEBS Lett, 2011 The ESCRT (endosomal sorting complex required for transport) pathway promotes the final membrane scission step at the end of cytokinesis, assists viral budding and generates multivesicular bodies (MVBs). These seemingly unrelated processes require a topologically similar membrane deformation and scission event that buds membranes/vesicles out of the ...
Adell MA, Teis D.
europepmc +5 more sources
Lipid accumulation controls the balance between surface connection and scission of caveolae [PDF]
eLife, 2020 Caveolae are bulb-shaped invaginations of the plasma membrane (PM) that undergo scission and fusion at the cell surface and are enriched in specific lipids.
Madlen Hubert +6 more
doaj +5 more sources