Results 11 to 20 of about 26,768 (226)
Viral membrane scission. [PDF]
Annu Rev Cell Dev Biol, 2013 Virus budding is a complex, multistep process in which viral proteins make specific alterations in membrane curvature. Many different viral proteins can deform the membrane and form a budding virion, but very few can mediate membrane scission to complete the budding process.
Rossman JS, Lamb RA.
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Friction Mediates Scission of Tubular Membranes Scaffolded by BAR Proteins [PDF]
Cell, 2017 International audienceMembrane scission is essential for intracellular trafficking. While BAR domain proteins such as endophilin have been reported in dynamin-independent scission of tubular membrane necks, the cutting mechanism has yet to be deciphered.
Bassereau, Patricia +12 more
core +11 more sources
Membrane scission by the ESCRT-III complex. [PDF]
Nature, 2009 The endosomal sorting complex required for transport (ESCRT) system is essential for multivesicular body biogenesis, in which cargo sorting is coupled to the invagination and scission of intralumenal vesicles. The ESCRTs are also needed for budding of enveloped viruses including human immunodeficiency virus 1, and for membrane abscission in cytokinesis.
Wollert T +3 more
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Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission. [PDF]
Sci Rep, 2017 AbstractMembrane scission is a crucial step in all budding processes, from endocytosis to viral budding. Many proteins have been associated with scission, though the underlying molecular details of how scission is accomplished often remain unknown. Here, we investigate the process of M2-mediated membrane scission during the budding of influenza viruses.
Martyna A +5 more
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ATP-dependent force generation and membrane scission by ESCRT-III and Vps4. [PDF]
Science, 2018 AbstractThe ESCRTs catalyze reverse-topology scission from the inner face of membrane necks in HIV budding, multivesicular endosome biogenesis, cytokinesis, and other pathways. We encapsulated a minimal ESCRT module consisting of ESCRT-III subunits Snf7, Vps24, and Vps2, and the AAA+ ATPase Vps4 such that membrane nanotubes reflecting the correct ...
Schöneberg J +11 more
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Influenza virus M2 protein mediates ESCRT-independent membrane scission. [PDF]
Cell, 2010 Many viruses utilize host ESCRT proteins for budding; however, influenza virus budding is thought to be ESCRT-independent. In this study we have found a role for the influenza virus M2 proton-selective ion channel protein in mediating virus budding. We observed that a highly conserved amphipathic helix located within the M2 cytoplasmic tail mediates a ...
Rossman JS, Jing X, Leser GP, Lamb RA.
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Regulation of membrane scission in yeast endocytosis. [PDF]
Mol Biol Cell, 2022 Yeast N-BAR protein complex Rvs regulates scission of clathrin-coated endocytic vesicles. Rvs is recruited by its curvature-sensing BAR domain as well as curvature independently by its SH3 domain. Rvs allows invagination growth by scaffolding the membrane and thereby delaying scission. Rvs also regulates the dynamics of the endocytic actin network.
Menon D, Hummel D, Kaksonen M.
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Autophagosome closure requires membrane scission. [PDF]
Autophagy, 2015 During the intracellular process of macroautophagy (hereafter autophagy), a membrane-bound organelle, the autophagosome, is generated de novo. The remodeling of the autophagic membrane during the life cycle of the organelle is a complex multistep process and involves several changes in the topology of the autophagic membrane.
Knorr RL, Lipowsky R, Dimova R.
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Membrane scission driven by the PROPPIN Atg18. [PDF]
EMBO J, 2017 Abstract Sorting, transport, and autophagic degradation of proteins in endosomes and lysosomes, as well as the division of these organelles, depend on scission of membrane‐bound tubulo‐vesicular carriers. How scission occurs is poorly understood, but family proteins bind these membranes.
Gopaldass N +4 more
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Reverse-topology membrane scission by the ESCRT proteins. [PDF]
Nat Rev Mol Cell Biol, 2017 The narrow membrane necks formed during viral, exosomal and intra-endosomal budding from membranes, as well as during cytokinesis and related processes, have interiors that are contiguous with the cytosol. Severing these necks involves action from the opposite face of the membrane as occurs during the well-characterized formation of coated vesicles ...
Schöneberg J +3 more
europepmc +7 more sources