Results 41 to 50 of about 12,869 (202)
Regulation of membrane scission in yeast endocytosis
, 2021 Abstract During clathrin-mediated endocytosis, a flat plasma membrane is shaped into an invagination that undergoes scission to form a vesicle. In mammalian cells, the force that drives the transition from invagination to vesicle is primarily provided by the GTPase dynamin that acts in concert with crescent-shaped BAR
Deepikaa Menon, Marko Kaksonen
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CryoEM structure of the super-constricted two-start dynamin 1 filament
Nature Communications, 2021 Dynamin mediates the fission of vesicles during endocytosis. Here, the authors report the cryoEM structure of a super-constricted two-start dynamin 1 filament- one of the two known helical forms of dynamin, with insights into the molecular mechanisms of ...
Jiwei Liu +4 more
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The mechanochemistry of endocytosis. [PDF]
PLoS Biology, 2009 Endocytic vesicle formation is a complex process that couples sequential protein recruitment and lipid modifications with dramatic shape transformations of the plasma membrane. Although individual molecular players have been studied intensively, how they
Jian Liu +3 more
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Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells
Frontiers in Cell and Developmental Biology, 2021 The 1-phosphatidylinositol-3-phosphate 5-kinase PIKfyve generates PtdIns3,5P2 on late phagolysosomes, which by recruiting the scission protein Atg18, results in their fragmentation in the normal course of endosome processing.
Yoko Yamada +6 more
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Cell Reports, 2017 Clathrin/adaptor protein-1-coated carriers connect the secretory and the endocytic pathways. Carrier biogenesis relies on distinct protein networks changing membrane shape at the trans-Golgi network, each regulating coat assembly, F-actin-based ...
Mihaela Anitei +10 more
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The AFF-1 exoplasmic fusogen is required for endocytic scission and seamless tube elongation
Nature Communications, 2018 Membrane fusion and fission events at exoplasmic membrane surfaces are not well understood. Here the authors show that the C. elegans cell–cell fusogen AFF-1 is required for endocytic scission and apically-directed membrane trafficking during the ...
Fabien Soulavie +2 more
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Stepwise remodeling and subcompartment formation in individual vesicles by three ESCRT-III proteins
iScience, 2023 Summary: The endosomal sorting complex required for transport (ESCRT) is a multi-protein machinery involved in several membrane remodeling processes. Different approaches have been used to resolve how ESCRT proteins scission membranes.
Yunuen Avalos-Padilla +6 more
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ESCRT-III-dependent and -independent egress of herpesviruses
Frontiers in VirologyEnveloped viruses complete their replication cycle by forming virions that bud from infected cells through membrane scission. The mechanisms by which this is achieved are less well-understood than the well-characterized membrane scission of vesicles ...
Jun Arii
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A noncanonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells. [PDF]
PLoS Biology, 2018 Dynamin Guanosine Triphosphate hydrolases (GTPases) are best studied for their role in the terminal membrane fission process of clathrin-mediated endocytosis (CME), but they have also been proposed to regulate earlier stages of CME.
Saipraveen Srinivasan +7 more
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A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling
eLife, 2021 Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki +5 more
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