Results 21 to 30 of about 26,768 (226)

FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. [PDF]

EMBO J, 2020
Degradation of endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomerization of ER-phagy receptor FAM134B (also referred to as reticulophagy regulator 1 or ...
Jiang X, Wang X, Ding X, Du M, Li B, Weng X, Zhang J, Li L, Tian R, Zhu Q, Chen S, Wang L, Liu W, Fang L, Neculai D, Sun Q.   +15 more
europepmc   +4 more sources

A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission. [PDF]

Nat Struct Mol Biol, 2020
AbstractThe ESCRT complexes drive membrane scission in HIV-1 release, autophagosome closure, MVB biogenesis, cytokinesis, and other cell processes. ESCRT-I is the most upstream complex and bridges the system to HIV-1 Gag in virus release. The crystal structure of the headpiece of human ESCRT-I comprising TSG101:VPS28:VPS37B:MVB12A was determined ...
Flower TG, Takahashi Y, Hudait A, Rose K, Tjahjono N, Pak AJ, Yokom AL, Liang X, Wang HG, Bouamr F, Voth GA, Hurley JH.   +11 more
europepmc   +8 more sources

Endophilin-A2 functions in membrane scission in clathrin-independent endocytosis. [PDF]

Nature, 2015
During endocytosis, energy is invested to narrow the necks of cargo-containing plasma membrane invaginations to radii at which the opposing segments spontaneously coalesce, thereby leading to the detachment by scission of endocytic uptake carriers. In the clathrin pathway, dynamin uses mechanical energy from GTP hydrolysis to this effect, assisted by ...
Renard HF, Simunovic M, Lemière J, Boucrot E, Garcia-Castillo MD, Arumugam S, Chambon V, Lamaze C, Wunder C, Kenworthy AK, Schmidt AA, McMahon HT, Sykes C, Bassereau P, Johannes L.   +14 more
europepmc   +5 more sources

Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. [PDF]

Proc Natl Acad Sci U S A, 2013
Significance Mitochondrial fission is critical for mammalian cell division, mitophagy, and development. Fission initiates via recruitment of dynamin-related GTPases to the mitochondrial surface. In yeast and human, the recruitment utilizes adaptors that differ in sequence and predicted structure.
Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM.   +6 more
europepmc   +4 more sources

Actin Dynamics Drive Membrane Reorganization and Scission in Clathrin-Independent Endocytosis [PDF]

Cell, 2010
Nascent transport intermediates detach from donor membranes by scission. This process can take place in the absence of dynamin, notably in clathrin-independent endocytosis, by mechanisms that are yet poorly defined. We show here that in cells scission of Shiga toxin-induced tubular endocytic membrane invaginations is preceded by cholesterol-dependent ...
Römer, Winfried, Pontani, Léa-Laetitia, Sorre, Benoît, Rentero, Carles, Berland, Ludwig, Chambon, Valérie, Lamaze, Christophe, Bassereau, Patricia, Sykes, Cécile, Gaus, Katharina, Ludger, Johannes   +10 more
openaire   +5 more sources

Bending and Scission: When the Membraneless Condensates Meet Endosome Membrane [PDF]

MedComm
Zhengkun Zhang, Feng Xie, Long Zhang
doaj   +3 more sources

Membrane deformation and scission by the HSV-1 nuclear egress complex [PDF]

Nature Communications, 2014
The nuclear egress complex (NEC) of herpesviruses such as HSV-1 is essential for the exit of nascent capsids from the cell nucleus. The NEC drives nuclear envelope vesiculation in cells, but the precise budding mechanism and the potential involvement of cellular proteins are unclear.
Bigalke, Janna M., Heuser, Thomas, Nicastro, Daniela, Heldwein, Ekaterina E.   +3 more
openaire   +4 more sources

Biomolecular condensates mediate bending and scission of endosome membranes

Nature
AbstractMultivesicular bodies are key endosomal compartments implicated in cellular quality control through their degradation of membrane-bound cargo proteins1–3. The ATP-consuming ESCRT protein machinery mediates the capture and engulfment of membrane-bound cargo proteins through invagination and scission of multivesicular-body membranes to form ...
Yanning Wang, Shulin Li, Marcel Mokbel, Alexander I. May, Zizhen Liang, Yonglun Zeng, Weiqi Wang, Honghong Zhang, Feifei Yu, Katharina Sporbeck, Liwen Jiang, Sebastian Aland, Jaime Agudo-Canalejo, Roland L. Knorr, Xiaofeng Fang   +14 more
openaire   +6 more sources

Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1. [PDF]

Proc Natl Acad Sci U S A, 2022
Cada AK, Pavlin MR, Castillo JP, Tong AB, Larsen KP, Ren X, Yokom AL, Tsai FC, Shiah JV, Bassereau PM, Bustamante CJ, Hurley JH.   +11 more
europepmc   +2 more sources

Assembly and disassembly of the ESCRT-III membrane scission complex.

FEBS Lett, 2011
The ESCRT (endosomal sorting complex required for transport) pathway promotes the final membrane scission step at the end of cytokinesis, assists viral budding and generates multivesicular bodies (MVBs). These seemingly unrelated processes require a topologically similar membrane deformation and scission event that buds membranes/vesicles out of the ...
Adell MA, Teis D.
europepmc   +4 more sources