Frontiers in Cellular and Infection Microbiology, 2021 The endosomal sorting complex required for transport (ESCRT) is formed by ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III complexes, and accessory proteins. It conducts vesicular trafficking in eukaryotes through the formation of vesicles and membrane fission and ...
Ausencio Galindo +8 more
doaj +1 more source
ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila.
PLoS ONE, 2014 Multivesicular endosome (MVE) sorting depends on proteins of the Endosomal Sorting Complex Required for Transport (ESCRT) family. These are organized in four complexes (ESCRT-0, -I, -II, -III) that act in a sequential fashion to deliver ubiquitylated ...
Emiliana Tognon +4 more
doaj +1 more source
Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes. [PDF]
, 2020 The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I. +6 more
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ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration [PDF]
Current Biology, 2007 Defects in the endosomal-lysosomal pathway have been implicated in a number of neurodegenerative disorders. A key step in the endocytic regulation of transmembrane proteins occurs in a subset of late-endosomal compartments known as multivesicular bodies (MVBs), whose formation is controlled by endosomal sorting complex required for transport (ESCRT ...
Lee, Jin-A. +4 more
openaire +3 more sources
A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I. [PDF]
, 2015 The Kaposi's sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC class I. K3 is an E3 ubiquitin ligase that promotes Lys(63)-linked polyubiquitination of MHC class I, providing the signal for clathrin ...
Boname, Jessica M +7 more
core +2 more sources
Changes in ESCRT-III filament geometry drive membrane remodelling and fission in silico
BMC Biology, 2019 Background ESCRT-III is a membrane remodelling filament with the unique ability to cut membranes from the inside of the membrane neck. It is essential for the final stage of cell division, the formation of vesicles, the release of viruses, and membrane ...
Lena Harker-Kirschneck +2 more
doaj +1 more source
Helical Structures of ESCRT-III Are Disassembled by VPS4 [PDF]
Science, 2008 During intracellular membrane trafficking and remodeling, protein complexes known as the ESCRTs (endosomal sorting complexes required for transport) interact with membranes and are required for budding processes directed away from the cytosol, including the budding of intralumenal vesicles to form multivesicular bodies; for the budding of some ...
Suman, Lata +6 more
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ESCRT-III and ER–PM contacts maintain lipid homeostasis [PDF]
Molecular Biology of the Cell, 2020 Saturating transposon mutagenesis screen identified the ESCRTs as synthetic genetic interactors in ER–PM contact mutant. The synthetic phenotype is caused by defects in lipid synthesis. Other ESCRT complexes, and VPS4 do not have a synthetic growth phenotype, indicating that only ESCRT-III proteins function in this lipid regulation pathway.
Jorgensen, Jeff R. +5 more
openaire +2 more sources
Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]
, 2017 Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas +5 more
core +2 more sources
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. [PDF]
, 2020 The AAA protein Msp1 extracts mislocalized tail-anchored membrane proteins and targets them for degradation, thus maintaining proper cell organization.
Myasnikov, Alexander +3 more
core +3 more sources