Results 61 to 70 of about 10,382 (181)
Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly
eLife, 2018 The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson +2 more
doaj +1 more source
PLoS Pathogens, 2021 Infection with Plasmodium falciparum enhances extracellular vesicle (EV) production in parasitized red blood cells (pRBCs), an important mechanism for parasite-to-parasite communication during the asexual intraerythrocytic life cycle.
Yunuen Avalos-Padilla +8 more
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah +3 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad +9 more
wiley +1 more source
Computational Model of Membrane Fission Catalyzed by ESCRT-III
PLoS Computational Biology, 2009 ESCRT-III proteins catalyze membrane fission during multi vesicular body biogenesis, budding of some enveloped viruses and cell division. We suggest and analyze a novel mechanism of membrane fission by the mammalian ESCRT-III subunits CHMP2 and CHMP3.
Gur Fabrikant +5 more
openaire +6 more sources
Membranumbau durch ESCRT-III-Proteine
BIOspektrum, 2022 AbstractTo maintain their function, cellular membranes require membrane remodelling, mediated by protein machineries like the ESCRT-III that deforms and breaks membranes in different cellular functions. Its mechanism of function is still unknown. However, recent findings on the ESCRT-IIIs’ structural and dynamic features, such as their ability to alter
openaire +1 more source
Advanced NanoBiomed Research, EarlyView.This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Interaction of AMSH with ESCRT-III and Deubiquitination of Endosomal Cargo [PDF]
Journal of Biological Chemistry, 2006 The "class E" vacuolar protein sorting (VPS) pathway mediates sorting of ubiquitinated cargo into the forming vesicles of the multivesicular bodies (MVB), and it is essential for down-regulation of signaling by growth factors and budding of enveloped viruses such as Ebola and HIV-1.
Agromayor, M, Martin-Serrano, J
openaire +3 more sources
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
eLife, 2017 Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1,
Nicole Monroe +4 more
doaj +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu +3 more
wiley +1 more source