Results 81 to 90 of about 10,382 (181)

ESCRT-III Dysfunction Causes Autophagosome Accumulation and Neurodegeneration [PDF]

Current Biology, 2007
Defects in the endosomal-lysosomal pathway have been implicated in a number of neurodegenerative disorders. A key step in the endocytic regulation of transmembrane proteins occurs in a subset of late-endosomal compartments known as multivesicular bodies (MVBs), whose formation is controlled by endosomal sorting complex required for transport (ESCRT ...
Lee, Jin-A., Beigneux, Anne, Ahmad, S. Tariq, Young, Stephen G., Gao, Fen-Biao   +4 more
openaire   +3 more sources

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, EarlyView.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source

Identification of Yeast Protein Sequences With Similarity to the ESCRT‐III Protein Snf7

Yeast, EarlyView.
ABSTRACT Endosomal sorting complex required for transport (ESCRT‐III) is a membrane remodeling complex involved in a large number of cellular processes. It appears to perform an essential function in eukaryotes, since to date no eukaryotic organism completely devoid of ESCRT‐III has been found.
Thomas Brune, Ralf Kölling
wiley   +1 more source

ESCRT-III and HIV-1 release [PDF]

Retrovirology, 2013
Enveloped viruses such as HIV-1 recruit ESCRT complexes (endosomal sorting complexes required for transport) to escape from cells. Although five complexes constitute the endosomal ESCRT machinery, only ESCRT-III and VPS4 are recruited to all ESCRT-catalyzed processes thereby executing membrane fission.
openaire   +1 more source

Structural Basis for ESCRT-III CHMP3 Recruitment of AMSH [PDF]

Structure, 2011
Endosomal sorting complexes required for transport (ESCRT) recognize ubiquitinated cargo and catalyze diverse budding processes including multivesicular body biogenesis, enveloped virus egress, and cytokinesis. We present the crystal structure of an N-terminal fragment of the deubiquitinating enzyme AMSH (AMSHΔC) in complex with the C-terminal region ...
Solomons, Julianna, Sabin, Charles, Poudevigne, Emilie, Usami, Yoshiko, Hulsik, David Lutje, Macheboeuf, Pauline, Hartlieb, Bettina, Göttlinger, Heinrich, Weissenhorn, Winfried   +8 more
openaire   +3 more sources

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

eLife, 2015
The endosomal sorting complexes required for transport (ESCRT) machinery mediates the physical separation between daughter cells during cytokinetic abscission.
Anna Caballe, Dawn M Wenzel, Monica Agromayor, Steven L Alam, Jack J Skalicky, Magdalena Kloc, Jeremy G Carlton, Leticia Labrador, Wesley I Sundquist, Juan Martin-Serrano   +9 more
doaj   +1 more source

ESCRT Machinery Mediates Cytokinetic Abscission in the Unicellular Red Alga Cyanidioschyzon merolae

Frontiers in Cell and Developmental Biology, 2020
In many eukaryotes, cytokinesis proceeds in two successive steps: first, ingression of the cleavage furrow and second, abscission of the intercellular bridge.
Fumi Yagisawa, Fumi Yagisawa, Takayuki Fujiwara, Takayuki Fujiwara, Takayuki Fujiwara, Tokiaki Takemura, Tokiaki Takemura, Yuki Kobayashi, Nobuko Sumiya, Shin-ya Miyagishima, Shin-ya Miyagishima, Shin-ya Miyagishima, Soichi Nakamura, Yuuta Imoto, Osami Misumi, Osami Misumi, Kan Tanaka, Haruko Kuroiwa, Tsuneyoshi Kuroiwa   +18 more
doaj   +1 more source