Results 81 to 90 of about 14,736 (216)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

ESCRT-III controls nuclear envelope deformation induced by progerin [PDF]

Scientific Reports, 2020
AbstractHutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder, caused by mutation in the gene encoding lamin A/C, which produces a truncated protein called progerin. In cells from HGPS patients, progerin accumulates at the nuclear membrane (NM), where it causes NM deformations. In this study, we investigated whether progerin-induced
Arii, Jun, Maeda, Fumio, Maruzuru, Yuhei, Koyanagi, Naoto, Kato, Akihisa, Mori, Yasuko, Kawaguchi, Yasushi   +6 more
openaire   +2 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

ESCRT-III on endosomes: new functions, new activation pathway

Biochemical Journal, 2016
The multivesicular body (MVB) pathway sorts ubiquitinated membrane cargo to intraluminal vesicles (ILVs) within the endosome, en route to the lysosomal lumen. The pathway involves the sequential action of conserved protein complexes [endosomal sorting complexes required for transport (ESCRTs)], culminating in the activation by ESCRT-II of ESCRT-III, a ...
openaire   +4 more sources

Timing of ESCRT-III protein recruitment and membrane scission during HIV-1 assembly

eLife, 2018
The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) proteins are critical for cellular membrane scission processes with topologies inverted relative to clathrin-mediated endocytosis.
Daniel S Johnson, Marina Bleck, Sanford M Simon   +2 more
doaj   +1 more source

ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast

, 2019
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms.
Charlotta Funaya, Dimitrios Papagiannidis, Giulia Ruffini, Jasmin A Schäfer, Julia P Schessner, Katharina Schaeff, Michael Knop, Oliver Pajonk, Peter W Bircham, Sebastian Schuck, Takuma Tsuji, Toyoshi Fujimoto, Vergères G   +12 more
core   +2 more sources

Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. [PDF]

, 2015
Compartmentalisation of cellular processes is fundamental to regulation of metabolism in Eukaryotic organisms and is primarily provided by membrane-bound organelles.
Achalkumar, Adell, Agromayor, Aimon, Alexa J. Cleasby, Angelova, Angelova, Apellaniz, Arriaga, Axelrod, Ayton, Bacia, Bagatolli, Barbara Ciani, Baumgart, Baumgart, Baumgart, Bayburt, Bayley, Beales, Beales, Beales, Benkoski, Bennett, Bergstrom, Bernchou, Bernchou, Betz, Bleicken, Boden, Boura, Boyle, Burns, Campillo, Carvalho, Cashikar, Castellana, Chan, Chen, Cho, Cho, Cho, Churchman, Ciani, Connell, Cremer, Cui, Dahlin, Das, Denisov, Diao, Durrieu, Eggeling, Elani, Elani, Epand, Fabrikant, Fletcher, Frolov, Fuertes, Girard, Goh, Goksu, Gordon, Gradišar, Harrison, Haswell, Haustein, Helfrich, Henriksen, Hiyama, Holthuis, Honigmann, Hurley, Härtel, Iwabuchi, Jena, Jeuken, Karamdad, Katayama, Kiessling, Korlach, Kozlov, Kozlov, Kraft, Lamblet, Langecker, Lata, Leduc, Lin, Lindau, Liu, Longo, Ly, Lyman, López-Montero, Maglia, Majd, Manley, Marsh, Marsh, Marsh, Marsh, Mart, Martens, Melikyan, Mercker, Monck, Montes, Moran-Mirabal, Nath, Nath, Neumann, Nourian, Olbrich, Osawa, Parasassi, Park, Parlati, Paul A. Beales, Pautot, Pautot, Pecreaux, Persson, Peterman, Przybylo, Rabe, Ramadurai, Ramakrishnan, Raschle, Rawicz, Richmond, Ritchie, Robson Marsden, Roux, Ruan, Rydell, Różycki, Saarikangas, Schoen, Schwille, Semrau, Serien, Shaklee, Shi, Shoemaker, Shum, Siegel, Simonsson, Simunovic, Sorre, Sorre, Sorre, Soumpasis, Stachowiak, Stachowiak, Stegmann, Studer, Suetsugu, Syeda, Szoka, Söllner, Takatsuki, Tanaka, Tanaka, Templer, Thomas, Thompson, Tian, Tonnesen, Troutier, Tsai, Tsurudome, Voeltz, Vogel, Wagner, Wang, Wang, Weber, Weidemann, Weinberger, Wetterau, Wieprecht, Wilson, Wollert, Wollert, Woodman, Woolfson, Worsfold, Xu, Yoon, Yu, Yu, Yuan, Zhang, Zhao, Zhu, Zick, Árnadóttir   +198 more
core   +2 more sources

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

eLife, 2017
Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1,
Nicole Monroe, Han Han, Peter S Shen, Wesley I Sundquist, Christopher P Hill   +4 more
doaj   +1 more source