Results 91 to 100 of about 14,736 (216)

Syntaxin 16 is a master recruitment factor for cytokinesis [PDF]

, 2013
Recently it was shown that both recycling endosome and endosomal sorting complex required for transport (ESCRT) components are required for cytokinesis, in which they are believed to act in a sequential manner to bring about secondary ingression and ...
Alexandra Kaupisch, Barr FA, Bastos RN, Bissig C, Blum R, Carlton J, Carlton JG, Carr CM, Chen X.-W., Chesneau L, Choudhury A, Dambournet D, Dulubova I, Elia N, Fededa JP, Fielding AB, Fielding AB, Francis A. Barr, Glotzer M, Goss JW, Gromley A, Guizetti J, Gwyn W. Gould, Hong W, Hélia Neto, Jung JJ, Lee HH, Louise L. Collins, Low SH, Manickam V, Mondal G, Munson M, Neto H, Prekeris R, Proctor KM, Rannou Y, Riggs KA, Scales SJ, Schiel JA, Schiel JA, Schiel JA, Schiel JA, Simon GC, Simonsen A, Struthers MS, Tellam JT, TerBush DR, Xu H, Zhang XM   +48 more
core   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

ESCRT-III and HIV-1 release [PDF]

Retrovirology, 2013
Enveloped viruses such as HIV-1 recruit ESCRT complexes (endosomal sorting complexes required for transport) to escape from cells. Although five complexes constitute the endosomal ESCRT machinery, only ESCRT-III and VPS4 are recruited to all ESCRT-catalyzed processes thereby executing membrane fission.
openaire   +1 more source

The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis

Nucleus, 2020
Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal.
Bailey A. Koch, Elizabeth Staley, Hui Jin, Hong-Guo Yu   +3 more
doaj   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms

Biology Open, 2019
The ESCRT pathway, comprising the in sequence acting ESCRT-0, -I, -II, -III and Vps4 complexes, conducts the abscission of membranes away from the cytosol.
Miriam Bäumers, Sven Klose, Christian Brüser, Carl Haag, Sebastian Hänsch, Hendrik Pannen, Stefanie Weidtkamp-Peters, Michael Feldbrügge, Thomas Klein   +8 more
doaj   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

The role of VPS4 in ESCRT-III polymer remodeling [PDF]

Biochemical Society Transactions, 2019
Abstract The endosomal sorting complex required for transport-III (ESCRT-III) and VPS4 catalyze a variety of membrane-remodeling processes in eukaryotes and archaea. Common to these processes is the dynamic recruitment of ESCRT-III proteins from the cytosol to the inner face of a membrane neck structure, their activation and filament ...
Caillat, Christophe, Maity, Sourav, Miguet, Nolwenn, Roos, Wouter, Weissenhorn, Winfried   +4 more
openaire   +4 more sources

In Vitro Membrane Remodeling by ESCRT is Regulated by Negative Feedback from Membrane Tension

iScience, 2019
Summary: Artificial cells can shed new light on the molecular basis for life and hold potential for new chemical technologies. Inspired by how nature dynamically regulates its membrane compartments, we aim to repurpose the endosomal sorting complex ...
Andrew Booth, Christopher J. Marklew, Barbara Ciani, Paul A. Beales   +3 more
doaj   +1 more source