Results 111 to 120 of about 14,736 (216)
Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance
Clinical Anatomy, EarlyView.ABSTRACT In recent decades, molecular biology and omics technologies have profoundly reshaped biomedical research, with genomics, proteomics, and other high‐throughput approaches dominating scientific agendas and funding priorities. Within this molecular paradigm, however, the anatomical sciences face an epistemic and institutional tension: morphology,
Katia Cortese, Marco Frascio
wiley +1 more source
ESCRT Machinery Mediates Cytokinetic Abscission in the Unicellular Red Alga Cyanidioschyzon merolae
Frontiers in Cell and Developmental Biology, 2020 In many eukaryotes, cytokinesis proceeds in two successive steps: first, ingression of the cleavage furrow and second, abscission of the intercellular bridge.
Fumi Yagisawa +18 more
doaj +1 more source
Genomic Inference of the Metabolism and Evolution of the Archaeal Phylum Aigarchaeota [PDF]
, 2018 Microbes of the phylum Aigarchaeota are widely distributed in geothermal environments, but their physiological and ecological roles are poorly understood.
Castelle, Cindy J. +14 more
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Interdisciplinary Medicine, EarlyView.Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi +6 more
wiley +1 more source
PLoS Pathogens, 2016 Kaposi's sarcoma-associated herpesvirus (KSHV) binding to the endothelial cell surface heparan sulfate is followed by sequential interactions with α3β1, αVβ3 and αVβ5 integrins and Ephrin A2 receptor tyrosine kinase (EphA2R).
Binod Kumar +8 more
doaj +1 more source
Frontotemporal Dementia Linked to Chromosome 3 in Saccharomyces cerevisiae [PDF]
, 2013 Frontotemporal dementia (FTD) represents a crippling new neurodegenerative disease for scientific investigation. Marked by characteristic frontal and temporal lobar cortical atrophy, FTD results in the progressive deterioration of social and behavioral ...
Sulkko, Niles
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Interdisciplinary Medicine, EarlyView.This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu +6 more
wiley +1 more source
CHMP1B is a target of USP8/UBPY regulated by ubiquitin during endocytosis.
PLoS Genetics, 2018 Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptor endocytosis and sorting towards either recycling vesicles or degradative lysosomes via multivesicular bodies (MVB). In this process, the endosomal
Xènia Crespo-Yàñez +8 more
doaj +1 more source
Regulation of midbody formation and function by mitotic kinases. [PDF]
, 2016 Cytokinesis is the final phase of cell division and safeguards the correct distribution of genomic and cytoplasmic materials between the two nascent daughter cells. The final separation, or abscission, of the daughter cells depends on the proper assembly
Capalbo, Luisa, D'Avino, Pier Paolo
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Migrasomes, Matrix‐Bound Nanovesicles, and More: Messengers in the Matrix
PROTEOMICS, EarlyView.ABSTRACT Extracellular vesicles (EVs) and particles (EPs) are diverse micro‐ and nanoparticles that circulate in bodily fluids and can attach to, or be deposited onto, the extracellular matrix (ECM) and other surfaces. To date, the nomenclature and classification of matrix‐bound or matrix‐associated EVs and EPs (MEVPs) have been unclear, largely due to
Anna V. Kolesov +3 more
wiley +1 more source