Results 121 to 130 of about 14,736 (216)

Computational Model of Membrane Fission Catalyzed by ESCRT-III

PLoS Computational Biology, 2009
ESCRT-III proteins catalyze membrane fission during multi vesicular body biogenesis, budding of some enveloped viruses and cell division. We suggest and analyze a novel mechanism of membrane fission by the mammalian ESCRT-III subunits CHMP2 and CHMP3.
Favrikant, G, Lata, S, Riches, JD, Briggs, JAG, Weissenhorn, W, Kozlov, MM   +5 more
openaire   +6 more sources

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

On the microstructure of active cellular processes [PDF]

, 2015
Eukaryotic cells use a multitude of protein machines to regulate their own structure. In this thesis, we study how the geometrical arrangement of these interacting microscopic active elements sculpt the cell's own internal microstructure and its membrane
Lenz, Martin
core   +2 more sources

Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein

Cell Reports, 2016
The endosomal sorting complex required for transport (ESCRT) is a conserved protein complex that facilitates budding and fission of membranes. It executes a key step in many cellular events, including cytokinesis and multi-vesicular body formation.
Brian J. McMillan, Christine Tibbe, Hyesung Jeon, Andrew A. Drabek, Thomas Klein, Stephen C. Blacklow   +5 more
doaj   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Cryo-EM structures of the ATP-bound Vps4E233Q hexamer and its complex with Vta1 at near-atomic resolution

Nature Communications, 2017
The ESCRT-III and Vps4 complexes mediate a variety of membrane remodelling events. Here the authors describe the structure of the Vps4 hexamer complexed to its cofactor Vta1, and show that Vta1 bridges adjacent Vps4 subunits to promote formation of the ...
Shan Sun, Lin Li, Fan Yang, Xiaojing Wang, Fenghui Fan, Mengyi Yang, Chunlai Chen, Xueming Li, Hong-Wei Wang, Sen-Fang Sui   +9 more
doaj   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Wrapping up the bad news: HIV assembly and release. [PDF]

, 2013
The late Nobel Laureate Sir Peter Medawar once memorably described viruses as 'bad news wrapped in protein'. Virus assembly in HIV is a remarkably well coordinated process in which the virus achieves extracellular budding using primarily intracellular ...
Lever, Andrew Ml, Meng, Bo
core   +3 more sources

Ligand‐induced ubiquitination regulates endocytosis and homeostasis of the ERECTA receptor kinase for stomatal development

New Phytologist, EarlyView.
Summary Stomatal patterning on the plant epidermis is regulated by the ERECTA family of leucine‐rich repeat receptor kinases (LRR‐RKs). While ubiquitination has emerged as a key regulatory mechanism for the endocytosis of receptor kinases, the precise molecular connections among ERECTA ubiquitination, endocytosis, and its biological functions remain ...
Liangliang Chen, Minh Huy Vu, Pengfei Bai, Alicia M. Cochran, Crystal F. Ying, Keiko U. Torii   +5 more
wiley   +1 more source