Results 131 to 140 of about 14,736 (216)
Aspergillus nidulans ambient pH signaling does not require endocytosis
, 2015 9 p.-6 fig.-1 tab.Aspergillus nidulans (Pal) ambient pH signaling takes place in cortical structures containing components of the ESCRT pathway, which are hijacked by the alkaline pH-activated, ubiquitin-modified version of the arrestin-like protein PalF
Arst, HN +3 more
core +1 more source
Genetic structure and evolution of the Vps25 family, a yeast ESCRT-II component [PDF]
, 2006 Background: Vps25p is the product of yeast gene VPS25 and is found in an endosomal sorting complex required for transport (ESCRT)-II, along with Vps22p and Vps36p.
Ruth Slater, Naomi E Bishop
core +2 more sources
The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity
The Journal of Physiology, EarlyView.Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas +5 more
wiley +1 more source
Membrane remodelling by dynamic ESCRT-III polymers
, 2021 Multi-subunit ESCRT-III polymers together with the ATPase Vps4 have the unique ability to fission membrane necks from their luminal side, a process that is required for essential cellular functions like cell division and nuclear envelop maintenance.
openaire +2 more sources
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.Schematic depicting isolation of extracellular vesicles (EVs) from brown adipose tissue (BAT) and their confirmation and quantification by proteomics analysis. The graphical abstract was created using BioRender.com. ABSTRACT Brown adipose tissue (BAT) is a thermogenic tissue that functions in an endocrine, paracrine, and autocrine manner.
Parth Pardeshi +6 more
wiley +1 more source
Journal of VirologyThe endosomal sorting complex required for transport (ESCRT) is a protein machine mediating membrane scission. In intraluminal vesicle (ILV) formation, ESCRT-0 targets cargoes and recruits ESCRT-I/-II to create membrane invagination, whereas ESCRT-III ...
Xiaorong Yue +5 more
doaj +1 more source
ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity
Nature Communications, 2018 The endosomal sorting complex required for transport-III (ESCRT-III) has been implicated in the packaging of HIV and HSV-1 viruses in the cytoplasm. Here the authors show that ESCRT-III proteins are required for the transport of HSV-1 nucleocapsids from ...
Jun Arii +9 more
doaj +1 more source
TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
Advanced Science, Volume 13, Issue 25, 4 May 2026.TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu +9 more
wiley +1 more source
A non-canonical ESCRT pathway, including His domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC Class I [PDF]
, 2015 The Kaposi’s sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC Class I. K3 is an E3 ubiquitin ligase that promotes K63-linked polyubiquitination of MHC Class I, providing the signal for clathrin ...
Boname, JM +7 more
core
Advanced Science, Volume 13, Issue 25, 4 May 2026.This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao +12 more
wiley +1 more source