Results 71 to 80 of about 10,382 (181)
BMEMat, EarlyView.MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen +10 more
wiley +1 more source
Nucleus, 2020 Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal.
Bailey A. Koch +3 more
doaj +1 more source
Biological Reviews, EarlyView.ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu +12 more
wiley +1 more source
ESCRT-III on endosomes: new functions, new activation pathway
Biochemical Journal, 2016 The multivesicular body (MVB) pathway sorts ubiquitinated membrane cargo to intraluminal vesicles (ILVs) within the endosome, en route to the lysosomal lumen. The pathway involves the sequential action of conserved protein complexes [endosomal sorting complexes required for transport (ESCRTs)], culminating in the activation by ESCRT-II of ESCRT-III, a ...
openaire +3 more sources
ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes
Journal of Cell Biology, 2020 The intraluminal vesicles (ILVs) of endosomes mediate the delivery of activated signaling receptors and other proteins to lysosomes for degradation, but they also modulate intercellular communication when secreted as exosomes. The formation of ILVs requires four complexes, ESCRT-0, -I, -II, and -III, with ESCRT-0, -I, and -II presumably involved in ...
Jorge Larios +3 more
openaire +3 more sources
Structural Basis for Regulation of ESCRT-III Complexes by Lgd [PDF]
Cell Reports, 2017 The ESCRT-III complex induces outward membrane budding and fission through homotypic polymerization of its core component Shrub/CHMP4B. Shrub activity is regulated by its direct interaction with a protein called Lgd in flies, or CC2D1A or B in humans.
Brian J. McMillan +5 more
openaire +3 more sources
The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms
Biology Open, 2019 The ESCRT pathway, comprising the in sequence acting ESCRT-0, -I, -II, -III and Vps4 complexes, conducts the abscission of membranes away from the cytosol.
Miriam Bäumers +8 more
doaj +1 more source
Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance
Clinical Anatomy, EarlyView.ABSTRACT In recent decades, molecular biology and omics technologies have profoundly reshaped biomedical research, with genomics, proteomics, and other high‐throughput approaches dominating scientific agendas and funding priorities. Within this molecular paradigm, however, the anatomical sciences face an epistemic and institutional tension: morphology,
Katia Cortese, Marco Frascio
wiley +1 more source
In Vitro Membrane Remodeling by ESCRT is Regulated by Negative Feedback from Membrane Tension
iScience, 2019 Summary: Artificial cells can shed new light on the molecular basis for life and hold potential for new chemical technologies. Inspired by how nature dynamically regulates its membrane compartments, we aim to repurpose the endosomal sorting complex ...
Andrew Booth +3 more
doaj +1 more source
Engineering Extracellular Vesicles: Strategies for Functional Modification and Clinical Translation
iNew Medicine, EarlyView.The engineering modification strategies of extracellular vesicles (EVs). This figure presents the four core technical systems for the engineering modification of EVs, including direct modification strategies (physical and chemical methods), biological engineering methods, and hybrid and bionic strategies.
Zhouming Cheng +3 more
wiley +1 more source