Results 91 to 100 of about 37,425 (325)

A single substitution in Vacuolar protein sorting 4 is responsible for resistance to watermelon mosaic virus in melon.

Journal of Experimental Botany, 2022
In plants, introgression of genetic resistances is a proven strategy for developing new resistant lines. While host proteins involved in genome replication and cell-to-cell movement are widely studied, other cell mechanisms responsible for virus ...
Aimeric Agaoua, V. Rittener, C. Troadec, C. Desbiez, A. Bendahmane, F. Moquet, C. Dogimont   +6 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. [PDF]

, 2015
Notch signaling is a major regulator of cell fate, proliferation, and differentiation. Like other signaling pathways, its activity is strongly influenced by intracellular trafficking.
Bray, Sarah J, Gomez-Lamarca, Maria J, Klein, Thomas, Seib, Ekatarina, Snowdon, Laura A   +4 more
core   +1 more source

ALIX is recruited temporarily into HIV-1 budding sites at the end of gag assembly.

PLoS ONE, 2014
Polymerization of Gag on the inner leaflet of the plasma membrane drives the assembly of Human Immunodeficiency Virus 1 (HIV-1). Gag recruits components of the endosomal sorting complexes required for transport (ESCRT) to facilitate membrane fission and ...
Pei-I Ku, Mourad Bendjennat, Jeff Ballew, Michael B Landesman, Saveez Saffarian   +4 more
doaj   +1 more source

Regulation of cargo transfer between ESCRT-0 and ESCRT-I complexes by flotillin-1 during endosomal sorting of ubiquitinated cargo

Oncogenesis, 2017
Ubiquitin-dependent sorting of membrane proteins in endosomes directs them to lysosomal degradation. In the case of receptors such as the epidermal growth factor receptor (EGFR), lysosomal degradation is important for the regulation of downstream ...
Melanie Meister, S. Bänfer, U. Gärtner, J. Koskimies, Monia Amaddii, R. Jacob, Ritva Tikkanen   +6 more
semanticscholar   +1 more source

Bro1 family proteins harmonize cargo sorting with vesicle formation

Bioessays, 2022
The Endosomal Sorting Complexes Required for Transport (ESCRTs) drive membrane remodeling in a variety of cellular processes that include the formation of endosomal intralumenal vesicles (ILVs) during multivesicular body (MVB) biogenesis.
Chun-che Tseng, R. Piper, D. Katzmann
semanticscholar   +1 more source

Genomic analysis of the endosomal sorting required for transport complex III pathway genes as therapeutic and prognostic biomarkers for endometrial carcinoma

Translational Cancer Research, 2022
The genes involved in the endosomal sorting required for transport complex (ESCRT)-III pathway is a protective mechanism that delays cell death by repairing damaged plasma membranes. We aimed to evaluate if targeting ESCRT-III genes may be used as biomarkers for predicting the clinical outcomes of endometrial carcinoma (EC).Transcriptome RNA sequence ...
Yang, Ye, Wang, Min
openaire   +2 more sources

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Subcellular trafficking of the Arabidopsis auxin influx carrier AUX1 uses a novel pathway distinct from PIN1 [PDF]

, 2006
The directional flow of the plant hormone auxin mediates multiple developmental processes, including patterning and tropisms. Apical and basal plasma membrane localization of AUXIN-RESISTANT1 (AUX1) and PIN-FORMED1 (PIN1) auxin transport components ...
Bennett, Malcolm, Dhonukshe, Pankaj, Friml, Jiri, Kleine-Vehn, Jürgen, Swarup, Ranjan   +4 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source